1119076-12-8

Basic information

• Product Name: (4-hydroxyphenyl)methyl nitrate
• Synonyms: (4-hydroxyphenyl)methyl nitrate
• CAS NO: 1119076-12-8
• Molecular Weight: 169.137
• Mol File: 1119076-12-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-hydroxyphenyl)methyl nitrate(CAS DataBase Reference)
• NIST Chemistry Reference: (4-hydroxyphenyl)methyl nitrate(1119076-12-8)
• EPA Substance Registry System: (4-hydroxyphenyl)methyl nitrate(1119076-12-8)

Safety Data

• Hazardous Substances Data: 1119076-12-8(Hazardous Substances Data)

Upstream product

• 35421-08-0 4-hydroxybenzyl chloride 

Downstream Products

• 1070804-76-0 4-(nitrooxymethyl)phenyl 4-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)benzoate 

Relevant articles and documents

Synthesis and biological evaluation of nitric oxide-donating thalidomide analogues as anticancer agents

In search of more potent anticancer agents, 15 nitric oxide (NO)-donating thalidomide analogues, 6a, 6b, 8a-8e, and 13a-13h, were designed and synthesized. Cytotoxicity of these compounds was evaluated in vitro against three human tumor cell lines (HepG2, A549, and PC-3). The results indicated that 13a-13d exhibited notable anticancer activities comparable to or stronger than that of 5-fluorouracil (5-FU). Structure-activity relationships were also discussed, based on the experimental data obtained. Generally, the cytotoxic activity of target compounds is closely related to the type of NO donors, and the length of the spacers connecting to NO donors also appears important for the bioactivities.