1119275-19-2Relevant articles and documents
Copper-catalysed three-component carboiodination of arynes: Expeditious synthesis of: O -alkynyl aryl iodides
Cao, Wenxuan,Niu, Sheng-Li,Shuai, Li,Xiao, Qing
supporting information, p. 972 - 975 (2020/02/03)
A copper-catalysed three-component iodoalkynylation reaction of arynes for the expeditious and versatile synthesis of o-alkynyl aryl iodides has been developed. Mechanism research shows that the reaction goes through two steps enabled by copper catalysis: the formation of 1-iodo-2-arylacetylene and the insertion of the aryne into a C(sp)-I bond.
P-TsOH Promoted Au(I)-Catalyzed Consecutive Endo Cyclization of Yne-Tethered Ynamide: Access to Benzofused Dihydroisoquinolones
Nayak, Sanatan,Ghosh, Nayan,Prabagar,Sahoo, Akhila K.
, p. 5662 - 5665 (2015/12/01)
A novel synthetic route to benzo[f]dihydroisoquinolone through a p-TsOH promoted cascade cyclization of easily accessible diyne-tethered ynamides in the presence of a Au(I)-catalyst is described. This reaction unveils a broad substrate scope, constructing a wide range of benzo[f]dihydroisoquinolones in good yields. The diyne-tethered ynamides are synthesized from inexpensive o-iodoaniline through Sonogashira couplings and the Cu-mediated C-N bond formation. The role of p-TsOH is examined, and the reaction pathway is also deduced. The benzo[f]isoquinoline scaffold is constructed from benzo[f]dihydroisoquinolones.
Synthesis and biological evaluation of novel symmetry bis-enediynes
Tseng, Kuo-Feng,Lin, Chi-Fong,Lo, Yu-Hsiang,Hu, Yi-Ling,Chen, Li-Yi,Yang, Sheng-Huei,Lin, Shinne-Ren,Chang, Long-Sen,Wu, Ming-Jung
experimental part, p. 35 - 41 (2009/04/07)
A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI
