1119451-34-1 Usage
Description
1-(4-chloro-1,2,5-thiadiazol-3-yl)azepane is a chemical compound characterized by the molecular formula C9H15ClN4S. It is a heterocyclic compound that features a seven-membered azepane ring fused with a thiadiazole ring. The thiadiazole ring is substituted with a chlorine atom, and the azepane ring contains a nitrogen atom. This unique structure and composition endow 1-(4-chloro-1,2,5-thiadiazol-3-yl)azepane with potential applications in the pharmaceutical and agrochemical industries. It is considered a promising building block for the synthesis of various biologically active compounds and is a subject of interest for its potential biological activities. Ongoing research in chemistry and pharmacology is focused on its synthesis and properties.
Uses
Used in Pharmaceutical Industry:
1-(4-chloro-1,2,5-thiadiazol-3-yl)azepane is used as a building block for the synthesis of biologically active compounds due to its unique structure and properties. It may contribute to the development of new drugs with specific therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical field, 1-(4-chloro-1,2,5-thiadiazol-3-yl)azepane is used as a starting material for the creation of novel compounds with potential pesticidal, herbicidal, or fungicidal properties. Its unique chemical structure allows for the exploration of its effectiveness in controlling various agricultural pests and diseases.
Used in Chemical Research:
1-(4-chloro-1,2,5-thiadiazol-3-yl)azepane is utilized as a subject of study in the fields of chemistry and pharmacology to understand its synthesis, properties, and potential biological activities. This research may lead to the discovery of new applications and uses for this compound in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1119451-34-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,1,9,4,5 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1119451-34:
(9*1)+(8*1)+(7*1)+(6*9)+(5*4)+(4*5)+(3*1)+(2*3)+(1*4)=131
131 % 10 = 1
So 1119451-34-1 is a valid CAS Registry Number.
1119451-34-1Relevant articles and documents
Thiadiazole carbamates: Potent inhibitors of lysosomal acid lipase and potential niemann-pick type C disease therapeutics
Rosenbaum, Anton I.,Cosner, Casey C.,Mariani, Christopher J.,Maxfield, Frederick R.,Wiest, Olaf,Helquist, Paul
supporting information; experimental part, p. 5281 - 5289 (2010/10/19)
Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized at the cellular level by abnormal accumulation of cholesterol and other lipids in lysosomal storage organelles. Lysosomal acid lipase (LAL) has been recently identified as a potential therapeutic target for NPC. LAL can be specifically inhibited by a variety of 3,4-disubstituted thiadiazole carbamates. An efficient synthesis of the C(3) oxygenated/C(4) aminated analogues has been developed that furnishes the products in high yields and high degrees of purity. Common intermediates can also be used for the synthesis of the C(3) carbon substituted derivatives. Herein we tested various thiadiazole carbamates, amides, esters, and ketones for inhibition of LAL. In addition, we tested a diverse selection of commercially available non-thiadiazole carbamates. Our studies show that, among the compounds examined herein, only thiadiazole carbamates are effective inhibitors of LAL. We present a mechanism for LAL inhibition by these compounds whereby LAL transiently carbamoylates the enzyme similarly to previously described inhibition of acetylcholinesterase by rivastigmine and other carbamates as well as acylation of various lipases by orlistat.
