112066-66-7Relevant articles and documents
Asymmetric Hydrogenation of β-Aryloxy/Alkoxy Cinnamic Nitriles and Esters
Kong, Duanyang,Li, Meina,Wang, Rui,Zi, Guofu,Hou, Guohua
supporting information, p. 4916 - 4919 (2016/10/18)
A highly efficient and enantioselective hydrogenation of β-aryloxy/alkoxy cinnamic nitriles and esters under mild conditions has been realized by using a rhodium catalyst with a chiral f-spiroPhos ligand. The method provides efficient access to the asymme
Chemoenzymatic synthesis of the non-tricyclic antidepressants Fluoxetine, Tomoxetine and Nisoxetine
Liu, Hui-Ling,Hoff, Bard Helge,Anthonsen, Thorleif
, p. 1767 - 1769 (2007/10/03)
3-Chloro-1-phenylpropan-1-ol and the corresponding butanoate, 3-chloro-1-phenyl-1-propyl butanoate, were kinetically resolved using lipase B from Candida antarctica catalysis by transesterification and hydrolysis respectively. The resulting chiral building blocks (S)- and (R)-3-chloro-1-phenylpropanol were converted into both enantiomers of the antidepressant drugs, Fluoxetine, Tomoxetine and Nisoxetine. The Royal Society of Chemistry 2000.