112083-27-9Relevant articles and documents
Asymmetric synthesis of (+)-negamycin
Davies, Stephen G.,Ichihara, Osamu
, p. 1919 - 1922 (1996)
(+)-Negamycin was synthesised employing the highly diastereoselective conjugate addition of lithium (α-methylbenzyl)benzylamide in the key step. The synthesis was completed in 13 steps starting from ethyl 4-chloroacetoacetate with an overall yield of 24%.
PREPARATION DE NOUVEAUX SYNTHONS CHIRAUX: LES β,γ-EPOXYESTERS; APPLICATION A LA SYNTHESE DE β-HYDROXYESTERS ENANTIOMERIQUEMENT PURS
Larcheveque, Marc,Henrot, Serge
, p. 1781 - 1782 (1987)
The preparation of optically pure β,γ-epoxyesters 3 has been achieved through the opening of 3-hydroxybutanolides with trimethylsilyliodide followed by cyclisation with silver oxyde.They react with organocuprates to afford β-hydroxyesters of high enantiomerical purity.
SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES
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Page/Page column 115, (2021/06/26)
Provided herein are pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.
A Concise Stereoselective Total Synthesis of Methoxyl Citreochlorols and Their Structural Revisions
Sunnapu, Ranganayakulu,Rajendar, Goreti
, p. 1637 - 1642 (2021/03/15)
A concise, stereoselective and protecting group free approaches for the total synthesis of (?)-(2S,4R)- and (+)-(2R,4S)-3′-methoxyl citreochlorols and their stereoisomers are demonstrated. All four stereoisomers were synthesized to establish the absolute stereochemistry of the reported structures and the structures were revised accordingly. The approach involves chelation controlled regioselective reduction of a diester, silyl iodide promoted ring-opening iodo esterification of lactones, highly chemo- and regioselective ring-opening of an epoxy ester, dichloromethylation of a carboxyl group, and syn- and anti-selective reduction of the resulted β-hydroxy ketone as key steps.
