112111-47-4

Basic information

• Product Name: (S)-Modafinil
• Synonyms: (S)-(+)-Modafinil;(S)-Modafinil;2-[(S)-(Diphenylmethyl)sulfinyl]acetamide;CRL 40983;ArModafinil IMpurity H;AcetaMide, 2-[(S)- (diphenylMethyl)sulfinyl]-;Acetamide,2-[(S)-(diphenylmethyl)sulfinyl]- (Related Reference);YFGHCGITMMYXAQ-IBGZPJMESA-N
• CAS NO: 112111-47-4
• Molecular Formula: C₁₅H₁₅NO₂S
• Molecular Weight: 273.354
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 112111-47-4.mol
• Article Data: 38

Chemical Properties

• Melting Point: 157-159°C
• Boiling Point: 559.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.283±0.06 g/cm3(Predicted)
• Storage Temp.: -20?C Freezer
• PKA: 14.88±0.40(Predicted)
• CAS DataBase Reference: (S)-Modafinil(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Modafinil(112111-47-4)
• EPA Substance Registry System: (S)-Modafinil(112111-47-4)

Safety Data

• Hazardous Substances Data: 112111-47-4(Hazardous Substances Data)

Usage

Description

(S)-Modafinil, also known as modafinil, is a eutectoid compound that is a wakefulness-promoting agent. It is the enantiopure (-)-enantiomer of racemic modafinil, which means it is the pure, non-mirror-image version of the compound. (S)-Modafinil is a white solid and is known for its ability to enhance cognitive function and alertness. It acts as a 1-adrenoceptor agonist, which contributes to its stimulating effects.

Uses

Used in Pharmaceutical Industry:
(S)-Modafinil is used as a therapeutic agent for the treatment of excessive sleepiness and other sleep disorders. It helps to improve wakefulness and alertness in individuals suffering from conditions such as narcolepsy, sleep apnea, and shift work sleep disorder. The compound's stimulating effects are attributed to its action as a 1-adrenoceptor agonist, which promotes wakefulness and cognitive function.
Additionally, (S)-Modafinil has been studied for its potential use in treating other conditions, such as attention deficit hyperactivity disorder (ADHD) and major depressive disorder (MDD), due to its cognitive-enhancing properties. However,

Upstream product

• 68524-30-1 2-(diphenylmethylthio)acetamide 
• 63547-24-0 modafinil acid 
• 91-01-0 1,1-Diphenylmethanol 
• 63547-22-8 (benzhydrylthio)acetic acid 
• 68524-29-8 benzhydrylsulfanyl acetyl chloride 
• 63547-25-1 methyl (S)-2-(benzhydrylsulfinyl)acetate 
• 79-07-2 Chloroacetamide 
• 118286-24-1 methyl diphenylmethylmercaptoacetate 
• 4237-48-3 diphenylmethanethiol 
• 63547-26-2 2-benzhydrylsulfanylacetonitrile 
• 63547-23-9 (diphenylmethyl)(ethyl acetate)sulfide 
• 118286-19-4 (diphenylmethyl)(ethyl acetate)sulfoxide 
• 776-74-9 Bromodiphenylmethane 
• 90-99-3 diphenylchloromethane 

Downstream Products

• 1502873-99-5 C₂₀H₁₉NO₅S 
• 1502874-00-1 C₁₉H₁₇NO₅S 

Relevant articles and documents

Spectroscopic and molecular modeling methods to investigate the interaction between psycho-stimulant modafinil and calf thymus DNA using ethidium bromide as a fluorescence probe

Interaction type of modafinil with calf thymus DNA (ct-DNA) was examined systematically using ethidium bromide (EB) as a fluorescence probe by fluorescence spectroscopy, UV–Vis spectroscopy, viscosity and molecular docking method. The fluorescence quenchi

Luminescent cis-Bis(bipyridyl)ruthenium(II) Complexes with 1,2-Azolylamidino Ligands: Photophysical, Electrochemical Studies, and Photocatalytic Oxidation of Thioethers

New 1,2-azolylamidino complexes cis-[Ru(bipy)2(NH=C(R)az*-κ2N,N)](OTf)2 (R = Me, Ph; az? = pz, indz, dmpz) are synthesized via chloride abstraction after a subsequent base-catalyzed coupling of a nitrile with the previously coordinated 1,2-azole. The synt

Alloxan-catalyzed biomimetic oxidations with hydrogen peroxide or molecular oxygen

Inspired by biological flavin catalysis, the nonionic alloxan derivatives were applied as the biomimetic catalysts for various oxidations, catalyzing oxidations of sulfides and amines with hydrogen peroxide or molecular oxygen under mild conditions with high yields in a short time. The whole catalytic cycle has been verified to be a biomimetic approach through the formation of the alloxan hydroperoxide reactive intermediate. Additionally, encouraging asymmetric catalytic results have been obtained with an easily prepared chiral alloxan in a sulfoxidation reaction.