112142-61-7

Basic information

• Product Name: Alanine, N-[N-(hydroxydiphenylacetyl)-2-methylalanyl]-2-methyl-
• CAS NO: 112142-61-7
• Molecular Formula: C22H26N2O5
• Molecular Weight: 398.459
• Mol File: 112142-61-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Alanine, N-[N-(hydroxydiphenylacetyl)-2-methylalanyl]-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Alanine, N-[N-(hydroxydiphenylacetyl)-2-methylalanyl]-2-methyl-(112142-61-7)
• EPA Substance Registry System: Alanine, N-[N-(hydroxydiphenylacetyl)-2-methylalanyl]-2-methyl-(112142-61-7)

Safety Data

• Hazardous Substances Data: 112142-61-7(Hazardous Substances Data)

Upstream product

• 112142-57-1 2-<2-(benzilamido)-2-methylpropionamido>-N,N,2-trimethylpropionamid 
• 111492-28-5 2-(2-Hydroxy-2,2-diphenylacetamido)-2-methylpropionsaeure 
• 111492-15-0 2-(2-Hydroxy-2,2-diphenylacetamido)-N,N,2-trimethylpropionamid 

Relevant articles and documents

3-(Dimethylamino)-2,2-dimethyl-2H-azirine as an α-Aminoisobutyric-Acid (Aib) Equivalent: Cyclic Depsipeptides via Direct Amide Cyclization

In MeCN at room temperature, 3-(dimethylamino)-2,2-dimethyl-2H-azirine (1) and α-hydroxycarboxylic acids react to give diamides of type 8.Selective cleavage of the terminal N,N-dimethylcarboxamide group in MeCN/H2O leads to the corresponding carboxylic acids 13.In toluene/PhSH, phenyl thioesters of type 11 are formed.Starting with diamides 8, the formation of morpholin-2,5-diones 10 has been achieved either by direct amide cyclization via intermediate 1,3-oxazol-5(4H)-ones 9 or via base-catalyzed cyclization of the phenyl thioesters 11.Reaction of carboxylic acids with 1, followed by selective amide hydrolysis, has been used for the construction of peptides from α-hydroxy carboxylic acids and repetitive α-aminoisobutyric-acid (Aib) units.Cyclization of 14a, 17a, and 20a with HCl in toluene at 100 deg C gave the 9-, 12-, and 15-membered cyclic depsipeptides 15, 18, and 21, respectively.