112152-17-7

Basic information

• Product Name: 3-Buten-2-ol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(1H-indol-4-yl)-2-methyl-, (E)-
• CAS NO: 112152-17-7
• Molecular Formula: C19H29NO2Si
• Mol File: 112152-17-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Buten-2-ol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(1H-indol-4-yl)-2-methyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-ol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(1H-indol-4-yl)-2-methyl-, (E)-(112152-17-7)
• EPA Substance Registry System: 3-Buten-2-ol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(1H-indol-4-yl)-2-methyl-, (E)-(112152-17-7)

Safety Data

• Hazardous Substances Data: 112152-17-7(Hazardous Substances Data)

Upstream product

• 112152-20-2 4-<2-(tributylstannyl)ethenyl>indole 
• 74685-00-0 1-(tert-butyldimethylsiloxy)-2-propanone 

Relevant articles and documents

Probing Ergot Alkaloid Biosynthesis: Synthesis and Feeding of a Proposed Intermediate along the Biosynthetic Pathway. A New Amidomalonate for Tryptophan Elaboration

The total synthesis of the diastereoisomeric amino acids 2 and their N-trideuteriomethyl analogues has been carried out.These compounds represent possible intermediates along the biosynthetic pathway from 4-(γ,γ-dimethylallyl)tryptophan (1) to the ergot alkaloids (e.g., 3a).The synthetic scheme features the preparation of an (indolylvinyl)metalic reagent from 4-ethynylindole via a hydrostannylation/metal-metal exchange sequence, as well as the preparation of dimethyl amino>malonate, a new amidomalonate reagent for tryptophan elaboration.Incorporation experiments with Claviceps sp.SD58 followed by GC-MS analysis of the major alkaloid, elymoclavine, showed that neither diastereomer of 2-d3 is an ergot alkaloid precursor.