1121600-04-1

Basic information

• Product Name: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 1121600-04-1
• Molecular Weight: 310.369
• Mol File: 1121600-04-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester(1121600-04-1)
• EPA Substance Registry System: 4-(4-fluoro-2-methoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester(1121600-04-1)

Safety Data

• Hazardous Substances Data: 1121600-04-1(Hazardous Substances Data)

Upstream product

• 450-88-4 1-bromo-4-fluoro-2-methoxybenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 102392-11-0 1-(4-fluoro-2-methoxyphenyl)piperazine 

Relevant articles and documents

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

NOVEL COMPOUND HAVING PARP INHIBITORY ACTIVITY

A compound represented by the following general formula (1) or a salt thereof. R1 represents a halogen atom and so on; R2 and R3 each represent a hydrogen atom and so on; R4 and R5 each represent a hy