112192-04-8 Usage
Uses
Roxindole Hydrochloride is a selective and potent presynaptic D-2 dopamine autoreceptor agonist.
Biological Activity
Dopamine D 2 autoreceptor agonist, with affinity for D 3 , D 4 and 5-HT 1 receptors (pK i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D 2 , D 3 , D 4 , 5-HT 1A , 5-HT 1B and 5-HT 1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 112192-04-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,9 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 112192-04:
(8*1)+(7*1)+(6*2)+(5*1)+(4*9)+(3*2)+(2*0)+(1*4)=78
78 % 10 = 8
So 112192-04-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2
112192-04-8Relevant articles and documents
A straightforward synthetic approach for roxindole
Lange, Jos H. M.,De Jong, Johannes C.,Sanders, Hans J.,Visser, Geb M.,Kruse, Chris G.
, p. 1055 - 1056 (2007/10/03)
A concise synthetic approach to the dopamine autoreceptor agonist roxindole 1 has been devised. The key step in the novel route is the addition of succinic anhydride to 5-methoxyindolylmagnesium bromide, which circumvents the cumbersome construction of th
