1122102-49-1

Basic information

• Product Name: C₁₈H₁₆N₃O₄^(1-)*Na⁽¹⁺⁾
• Synonyms: C₁₈H₁₆N₃O₄^(1-)*Na⁽¹⁺⁾
• CAS NO: 1122102-49-1
• Molecular Weight: 361.333
• Mol File: 1122102-49-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₆N₃O₄^(1-)*Na⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₆N₃O₄^(1-)*Na⁽¹⁺⁾(1122102-49-1)
• EPA Substance Registry System: C₁₈H₁₆N₃O₄^(1-)*Na⁽¹⁺⁾(1122102-49-1)

Safety Data

• Hazardous Substances Data: 1122102-49-1(Hazardous Substances Data)

Upstream product

• 1122102-44-6 C₂₅H₂₆N₃O₇^(1-)*Na⁽¹⁺⁾ 

Downstream Products

• 65-49-6 4-Aminosalicylic acid 

Relevant articles and documents

Colon-specific mutual amide prodrugs of 4-aminosalicylic acid for their mitigating effect on experimental colitis in rats

Mutual amide prodrugs of 4-aminosalicylic acid with d-phenylalanine and l-tryptophan were synthesized for targeted drug delivery to the inflamed gut tissue in inflammatory bowel disease. Stability studies in aqueous buffers (pH 1.2 and 7.4) showed that the synthesized prodrugs were stable in both the buffers over a period of 10 h. In rat fecal matter the release of 4-aminosalicylic acid from the prodrugs was in the range of 86-91% over a period of 20 h, with half-lives ranging between 343 and 412 min following first order kinetics. Targeting potential of the carrier system and the ameliorating effect of the amide conjugates were evaluated in trinitrobenzenesulfonic acid-induced experimental colitis model in rats. The prodrugs were assessed for their probable damaging effects on pancreas and liver with the help of histopathological analysis and for their ulcerogenic potential by Rainsford's cold stress method. They were found to have improved safety profile than sulfasalazine, oral 4- and 5-aminosalicylic acid with similar pharmacological spectrum and advantages of sulfasalazine.