112302-87-1

Basic information

• Product Name: DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester
• CAS NO: 112302-87-1
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.37
• Mol File: 112302-87-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester(112302-87-1)
• EPA Substance Registry System: DL-Alanine, N,N-bis(phenylmethyl)-, methyl ester(112302-87-1)

Safety Data

• Hazardous Substances Data: 112302-87-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 145147-70-2 N,N-dibenzylalanine 
• 1408233-59-9 C₁₁H₁₃NO₅S 
• 1589-82-8 phenylmagnesium bromide 
• 1408233-60-2 C₁₀H₂₁NO₃Si 
• 52742-32-2 N,N-dibenzyl-O-benzoylhydroxylamine 
• 34880-70-1 [1-methoxyprop-1-enyloxy]trimethylsilane 
• 13515-97-4 methyl 2-aminopropanoate monohydrochloride 
• 100-39-0 benzyl bromide 
• 5445-17-0 Methyl 2-bromopropionate 
• 103-49-1 dibenzylamine 
• 94226-55-8 (dibenzylamino)acetic acid methyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 7625-53-8 rac-Ala-OMe 
• 1279700-00-3 3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-one 
• 1433460-27-5 C₃₉H₄₀N₂O₂ 
• 1433460-26-4 methyl 3-(4-cyanophenyl)-2-(dibenzylamino)propanoate 
• 1433460-20-8 methyl 2-(dibenzylamino)-3-(4-fluorophenyl)propanoate 
• 112302-89-3 methyl 2-(N,N-dibenzylamino)-3-phenylpropanoate 
• 1433460-23-1 methyl 2-(dibenzylamino)-3-(3-fluoro-4-methoxyphenyl)propanoate 
• 1433460-24-2 methyl 2-(dibenzylamino)-3-(2-fluorophenyl)propanoate 
• 1433460-28-6 methyl 2-(dibenzylamino)-3-(3,4-dimethoxyphenyl)propanoate 
• 1433460-29-7 methyl 2-(dibenzylamino)-3-(naphthalene-2-yl)propanoate 
• 1433460-30-0 methyl 3-(biphenyl-4-yl)-2-(dibenzylamino)propanoate 
• 1433460-31-1 methyl 2-(dibenzylamino)-3-(thiophen-2-yl)propanoate 
• 1433460-32-2 methyl 2-(dibenzylamino)-3-(furan-3-yl)propanoate 
• 1433460-33-3 methyl 2-(dibenzylamino)-3-(pyridin-3-yl)propanoate 

Relevant articles and documents

Palladium-catalyzed β-arylation of silyl ketene acetals and application to the synthesis of benzo-fused δ-lactones

Silyl ketene acetals are shown to be competent nucleophiles in Pd-catalyzed migrative C(sp3)-H arylations. Compared to the parent ester lithium enolates, they possess decreased reactivity but enhanced chemoselectivity. This behavior was exploited through the synthesis of valuable benzo-fused δ-lactones such as 1-isochromanones and dihydrocoumarins.

Copper-catalyzed amination of ketene silyl acetals with hydroxylamines: Electrophilic amination approach to α-amino acids

Role reversal: The title reaction has been developed to deliver α-amino acids under very mild reaction conditions (see scheme; dpppen=1,5-bis(diphenylphosphino)pentane). The catalysis provides a new C-N bond-forming approach for the synthesis of α-amino a

Highly enantioselective access to α-dibenzylamino ketones from chiral nonracemic α-bromo α′-sulfinyl ketones by dynamic kinetic resolution: Synthesis of (2R,1′S)-2-[1-(dibenzylamino)alkyl]oxiranes

A novel and efficient synthesis of enantiomerically pure α-dibenzylamino α′-sulfinyl ketones starting from a mixture of both epimers of α-bromo α′-(R)-sulfinyl ketone has been realized through combined in situ substitution-epimerization in a so-called Dynamic Kinetic Resolution (DKR). The scope of the reaction has been examined, and four differently substituted α-(S)-dibenzylamino α′-(R)- sulfinyl ketones were obtained in good yields with excellent diastereoselectivities. The utility of these derivatives was further illustrated with a highly stereoselective synthesis of syn-(2R,1′S)-2-(1- dibenzylaminoalkyl)oxiranes.