1123819-05-5

Basic information

• Product Name: C₂₅H₂₂ClN₃O₂
• CAS NO: 1123819-05-5
• Molecular Weight: 431.922
• Mol File: 1123819-05-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₂ClN₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₂ClN₃O₂(1123819-05-5)
• EPA Substance Registry System: C₂₅H₂₂ClN₃O₂(1123819-05-5)

Safety Data

• Hazardous Substances Data: 1123819-05-5(Hazardous Substances Data)

Upstream product

• 1123819-43-1 C₂₀H₁₃ClN₂O₃ 
• 62893-54-3 2-(cyclopropyl)ethylamine 
• 619-05-6 3,4-diaminobenzoic acid 

Relevant articles and documents

Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization

The discovery of potent benzimidazole stearoyl-CoA desaturase (SCD1) inhibitors by ligand-based virtual screening is described. ROCS 3D-searching gave a favorable chemical motif that was subsequently optimized to arrive at a chemical series of potent and promising SCD1 inhibitors. In particular, compound SAR224 was selected for further pharmacological profiling based on favorable in vitro data. After oral administration to male ZDF rats, this compound significantly decreased the serum fatty acid desaturation index, thus providing conclusive evidence for SCD1 inhibition in vivo by SAR224.