112423-14-0Relevant articles and documents
Highly c3-selective direct alkylation and arylation of 2-pyridones under visible-light-promoted photoredox catalysis
Najib, Atifah,Tabuchi, Sho,Hirano, Koji,Miura, Masahiro
, p. 1187 - 1203 (2016)
An Ir photoredox catalyst-mediated highly site-selective direct alkylation and arylation of 2-pyridones has been developed. Under visible-light-promoted conditions, ethyl 2-bromo-2,2-difluoroacetate couples with various 2-pyridones exclusively at the C3 position. A similar photoredox catalysis is also effective for the direct C3- Arylation with diaryliodonium triflates. Thus, these reactions occurs under very mild conditions (blue LEDs irradiation and ambient temperature) to form the corresponding C3- Alkylated and arylated 2-pyridones of potential interest in medicinal and pharmaceutical chemistry.
A convenient access to furo[3,2-c]pyridin-6(5H)-ones by the reaction of 5-iodo-4-methoxy-2-pyridones with terminal alkynes under microwave-enhanced Sonogashira conditions
Conreaux, David,Delaunay, Thierry,Desbordes, Philippe,Monteiro, Nuno,Balme, Geneviève
experimental part, p. 3299 - 3301 (2009/08/09)
N-Alkyl-3-aryl-5-iodo-4-methoxypyridin-2(1H)-ones readily undergo sequential acetylide cross-coupling, demethylation, and furan annulation under classical Sonogashira reaction conditions to furnish 7-arylfuro[3,2-c]pyridin-4(5H)-ones, a class of hitherto
