1124329-11-8

Basic information

• Product Name: 9-cyclopentyl-2-{[2-fluoro-4-(methylsulfonyl)phenyl]amino}-7-methyl-7,9-dihydro-8H-purin-8-one
• Synonyms: 9-cyclopentyl-2-{[2-fluoro-4-(methylsulfonyl)phenyl]amino}-7-methyl-7,9-dihydro-8H-purin-8-one
• CAS NO: 1124329-11-8
• Molecular Weight: 405.453
• Mol File: 1124329-11-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-cyclopentyl-2-{[2-fluoro-4-(methylsulfonyl)phenyl]amino}-7-methyl-7,9-dihydro-8H-purin-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-cyclopentyl-2-{[2-fluoro-4-(methylsulfonyl)phenyl]amino}-7-methyl-7,9-dihydro-8H-purin-8-one(1124329-11-8)
• EPA Substance Registry System: 9-cyclopentyl-2-{[2-fluoro-4-(methylsulfonyl)phenyl]amino}-7-methyl-7,9-dihydro-8H-purin-8-one(1124329-11-8)

Safety Data

• Hazardous Substances Data: 1124329-11-8(Hazardous Substances Data)

Upstream product

• 832755-13-2 2-fluoro-4-methanesulfonylaniline 
• 1124329-94-7 2-chloro-9-cyclopentyl-7-methyl-7H-purin-8(9H)-one 

Relevant articles and documents

2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

The invention relates to chemical compounds of the formula (I), or a pharmaceutically acceptable salt thereof, which possess inhibitory activity against the spindle checkpoint kinase: Tyrosine Threonine Kinase (TTK)/monopolar spindle 1 (Mpsl) and are accordingly useful for their anti-cancer effect in a warm-blooded animal such as man. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of a medicament for the treatment of conditions mediated by TTK/Mpsl, for use either alone or in combination with other anti-pro liferative agents.