1124329-14-1 Usage
Description
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one is a complex organic compound with a molecular structure that features a cyclopentyl group, a methoxy-substituted phenyl ring, and a piperidinyl moiety. 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one is characterized by its potential biological activities and applications in various fields, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one is used as a protein kinase Mps1 inhibitor for its potential role in the treatment of various cancers. As a potent and selective inhibitor of Mps1/TTK kinase, it plays a crucial role in the spindle assembly checkpoint, which is essential for proper cell division. By inhibiting this kinase, the compound can disrupt the cell division process, leading to the inhibition of cancer cell growth.
Used in Anticancer Applications:
In the field of oncology, 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one demonstrates its potential as an anticancer agent. It has been shown to decrease the growth of hepatocellular carcinoma in vitro, specifically in SMMC-7721 and BEL-7404 cell lines. The compound's ability to target the Mps1 kinase makes it a promising candidate for further research and development in cancer therapy.
Used in Drug Development and Research:
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one can also be utilized in drug development and research as a lead compound or a chemical probe to investigate the role of Mps1 kinase in various cellular processes. Its structural features and biological activities make it a valuable tool for understanding the underlying mechanisms of cancer cell division and the potential for targeted therapeutic intervention.
References
1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25
2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309
Check Digit Verification of cas no
The CAS Registry Mumber 1124329-14-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,2,4,3,2 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1124329-14:
(9*1)+(8*1)+(7*2)+(6*4)+(5*3)+(4*2)+(3*9)+(2*1)+(1*4)=111
111 % 10 = 1
So 1124329-14-1 is a valid CAS Registry Number.
1124329-14-1Relevant articles and documents
2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
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Page/Page column 67, (2009/04/25)
The invention relates to chemical compounds of the formula (I), or a pharmaceutically acceptable salt thereof, which possess inhibitory activity against the spindle checkpoint kinase: Tyrosine Threonine Kinase (TTK)/monopolar spindle 1 (Mpsl) and are accordingly useful for their anti-cancer effect in a warm-blooded animal such as man. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of a medicament for the treatment of conditions mediated by TTK/Mpsl, for use either alone or in combination with other anti-pro liferative agents.
