112537-96-9 Usage
Description
5-Nitro-2-furfuraldazine is an organic compound that serves as an impurity in the synthesis of Nitrofurazone (N493880), which is an anti-infective agent used topically. It is characterized by its chemical structure and properties, which contribute to its presence in the synthesis process of the anti-infective drug.
Uses
Used in Pharmaceutical Industry:
5-Nitro-2-furfuraldazine is used as an impurity in the synthesis of Nitrofurazone, an anti-infective agent. Its presence is significant in the production process of the drug, as it contributes to the overall synthesis and effectiveness of the final product.
Used in Antimicrobial Applications:
As a component in the synthesis of Nitrofurazone, 5-Nitro-2-furfuraldazine plays a role in the development of antimicrobial agents. Nitrofurazone, which is derived from this synthesis process, is known for its antimicrobial properties and is used topically to treat various infections.
Used in Drug Synthesis:
5-Nitro-2-furfuraldazine is utilized in the synthesis of Nitrofurazone USP Related Compound A, which is an important compound in the pharmaceutical industry. Its involvement in the synthesis process highlights its importance in the development of drugs with specific therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 112537-96-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,5,3 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 112537-96:
(8*1)+(7*1)+(6*2)+(5*5)+(4*3)+(3*7)+(2*9)+(1*6)=109
109 % 10 = 9
So 112537-96-9 is a valid CAS Registry Number.
112537-96-9Relevant articles and documents
Identification of the photolysis products of nitrofurazone irradiated with laboratory illumination
Quilliam, Michael A.,McCarry, Brian E.,Hoo, Ken H.,McCalla, Dennis R.,Vaitekunas, Susan
, p. 1128 - 1132 (2007/10/02)
Illumination of aqueous or organic solutions of nitrofurazone, 1, with fluorescent or tungsten light caused the appearance of two new compounds, 2 and 3.Compound 2, which eluted just before nitrofurazone on a reverse phase hplc column, had a mass spectrum identical to that of 1 and converted back to 1 at a rate proportional to the temperature and the polarity of the solvent when allowed to sit in the dark.High resolution proton nmr spectroscopy provided conclusive evidence that compound 2 is the syn isomer of 1.Compound 3 had a retention time, ultraviolet spectrum, and mass spectrum that were indistinguishable from those of synthetic 5-nitrofuraldehyde azine.The toxicity of 3 to E. coli was determined to be the same as 1 while its mutagenicity was over 10-fold lower.No detectable cross-links were formed in the DNA of E. coli in the presence of compound 3.Thus, it is unlikely that the relatively small amounts of the azine 3 formed have much influence on the antibacterial potency or mutagenicity of nitrofurazone solutions.However, these results do confirm the desirability of conducting experiments with these agents in the dark or under yellow light.Photochemical formation of syn isomers was also observed with two other Schiff's base nitrofuran derivatives, nitrofurantoin and furazolidone.
