112671-96-2

Basic information

• Product Name: 2-Thiophenecarboxamide, N-(2-oxo-2-phenylethyl)-
• CAS NO: 112671-96-2
• Molecular Formula: C13H11NO2S
• Molecular Weight: 245.302
• Mol File: 112671-96-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Thiophenecarboxamide, N-(2-oxo-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxamide, N-(2-oxo-2-phenylethyl)-(112671-96-2)
• EPA Substance Registry System: 2-Thiophenecarboxamide, N-(2-oxo-2-phenylethyl)-(112671-96-2)

Safety Data

• Hazardous Substances Data: 112671-96-2(Hazardous Substances Data)

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 527-72-0 2-thiophenylcarboxylic acid 
• 1816-88-2 2-azido-1-phenylethan-1-one 

Downstream Products

• 149286-07-7 Acetic acid (S)-1-phenyl-2-[(thiophene-2-carbonyl)-amino]-ethyl ester 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 149286-02-2 Thiophene-2-carboxylic acid ((R)-2-hydroxy-2-phenyl-ethyl)-amide 
• 187144-59-8 Thiophene-2-carboxylic acid (2-hydroxy-2-phenyl-ethyl)-amide 
• 96461-08-4 5-phenyl-2-(thiophen-2-yl)thiazole 

Relevant articles and documents

Synthesis method of alpha-acylamino ketone compound

The invention discloses a synthesis method of an alpha-acylamino ketone compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: mixingan alkenyl azide compound 1, a carboxylic acid compound 2 and an organic solvent, and heating to react to obtain the alpha-acylamino ketone compound 3. Compared with the prior art, the method has thefollowing advantages: (1) the synthesis process is simple and efficient, no catalyst is needed in the whole process, and the alpha-acylamino ketone compound can be obtained with high yield by dissolving the alkenyl azide compound and the carboxylic acid compound in the solvent and stirring; (2) raw materials are cheap and easy to obtain, reaction conditions are mild, and operation is simple; (3) the substrate is wide in application range and can be used for modifying drug molecules; and (4) the atom economy is high, and the requirements of green chemistry are met.

Baker's Yeast Reduction of α-(Acylamino)acetophenones and Lipase Catalyzed Resolution of 2-Acylamino-1-arylethanols

Enzymatic reduction of α-acylaminoacetophenones with fermenting baker's yeast afforded optically active (R)-2-acylamino-1-arylethanols.Furthermore, lipase-catalyzed resolution of the 2-acylamino-1-arylethanols using vinyl acetate as an acyl donor resulted in the formation of (S)-1-acetoxy-2-acylamino-1-arylethanols and (R)-2-acylamino-1-arylethanols.