112681-19-3

Basic information

• Product Name: 2-(4-bromophenyl)-2-hydroxy-N-phenylacetamide
• Synonyms: 2-(4-bromophenyl)-2-hydroxy-N-phenylacetamide
• CAS NO: 112681-19-3
• Molecular Weight: 306.159
• Mol File: 112681-19-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)-2-hydroxy-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-2-hydroxy-N-phenylacetamide(112681-19-3)
• EPA Substance Registry System: 2-(4-bromophenyl)-2-hydroxy-N-phenylacetamide(112681-19-3)

Safety Data

• Hazardous Substances Data: 112681-19-3(Hazardous Substances Data)

Upstream product

• 99-90-1 para-bromoacetophenone 
• 62-53-3 aniline 
• 591-50-4 iodobenzene 
• 21165-18-4 2-(4-bromophenyl)-2-hydroxyacetamide 
• 6940-50-7 4-bromo-DL-mandelic acid 
• 1197040-29-1 phenyl isocyanate 
• 1122-91-4 4-bromo-benzaldehyde 

Relevant articles and documents

Zirconium-MOF-catalysed selective synthesis of α-hydroxyamide via the transfer hydrogenation of α-ketoamide

This work reports the synthesis of α-hydroxy amide and its derivatives using zirconium-based metal-organic frameworks (Zr-MOFs). The Zr-MOF was prepared using a ligand containing different functionalities as a linker with different porosities. The catalyst efficiently facilitated the transfer hydrogenation of α-ketoamide to α-hydroxyamide. The reaction involved a green hydrogen source, namely isopropyl alcohol, which also acted as a solvent. The role of the ligand in the catalyst was optimized for the selective conversion of α-ketoamide to α-hydroxyamide. UiO-66 (Zr) crystal was efficiently used for the first time for the hydrogenation of α-ketoamide to α-hydroxyamide. The catalyst was recovered and recycled five times without any loss in activity and selectivity performance. The morphology, activity and stability of the UiO-66 (Zr) catalyst were analyzed using field emission gun scanning electron microscopy (FEG-SEM), X-ray diffraction (XRD), infra-red (IR) spectroscopy and thermogravimetric analysis (TGA). The existence of α-hydroxyamide and its derivatives was confirmed from 1H and 13C-NMR.

Synthesis of α-Hydroxycarboxylic Acid Anilides via Copper-Catalyzed C-N Coupling of α-Hydroxyamides with Aryl Halides

The synthesis of highly important α-hydroxycarboxylic acid anilides via copper-catalyzed chemoselective C-N coupling reactions of α-hydroxyamides and aryl halides is described. This highly selective N-arylation process demonstrates wide substrate scope, c

PREPARATION OF SOME STABLE AND TRANSIENT 1,3-OXAZOLIUM-4-OLATES

A number of mandelanilides (6) were prepared and oxidized with barium manganate to phenylglyoxanilides (7).The latter were converted to N-benzoylglyoxanilides which, upon heating with triethyl phosphite, gave the corresponding 1,3-oxazolium-4-olates (2).