1126895-95-1

Basic information

• Product Name: (R)-6-chloro-1-(4-methoxybenzyl)-4-(2-oxopropyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
• Synonyms: (R)-6-chloro-1-(4-methoxybenzyl)-4-(2-oxopropyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
• CAS NO: 1126895-95-1
• Molecular Weight: 426.823
• Mol File: 1126895-95-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-6-chloro-1-(4-methoxybenzyl)-4-(2-oxopropyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-6-chloro-1-(4-methoxybenzyl)-4-(2-oxopropyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one(1126895-95-1)
• EPA Substance Registry System: (R)-6-chloro-1-(4-methoxybenzyl)-4-(2-oxopropyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one(1126895-95-1)

Safety Data

• Hazardous Substances Data: 1126895-95-1(Hazardous Substances Data)

Upstream product

• 541-50-4 2-acetoacetic acid 
• 497235-37-7 6-chloro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)hydroquinazolin-2-one 

Relevant articles and documents

Hydrogen-bond-directed enantioselective decarboxylative mannich reaction of β-ketoacids with ketimines: Application to the synthesis of anti-HIV drug DPC 083

Key to success: The title reaction provides facile access to enantioenriched 3,4-dihydroquinazolin-2(1H)-ones containing a quaternary stereogenic center in high yields with excellent enantioselectivities. Subsequent transformations lead to the convenient preparation of the anti-HIV drug DPC 083 and N-fused polycyclic compounds without loss of enantiomeric excess.