112700-37-5Relevant articles and documents
Expanding the scope of oligo-pyrrolinone-pyrrolidines as protein-protein interface mimics
Raghuraman, Arjun,Xin, Dongyue,Perez, Lisa M.,Burgess, Kevin
, p. 4823 - 4833 (2013/07/05)
Oligo-pyrrolinone-pyrrolidines (generic structure 1) have the potential to interfere with protein-protein interactions (PPIs), but to reduce this to practice it is necessary to be able to synthesize these structures with a variety of different side chains
A synthetic approach to diverse 3-acyltetramic acids via O- to C-acyl rearrangement and application to the total synthesis of penicillenol series
Sengoku, Tetsuya,Nagae, Yuta,Ujihara, Yasuaki,Takahashi, Masaki,Yoda, Hidemi
scheme or table, p. 4391 - 4401 (2012/06/18)
For the efficient approach to medicinally important α-branched 3-acyltetramic acids, the key reaction of O- to C- acyl rearrangement using α-amino-acid-derived 4-O-acyltetramic acids was extensively examined in the presence of various metal salts. Use of
Synthesis of N-substituted 3-ammomethylidenetetramic acids
Pirc, Samo,Bevk, David,Jakse, Renata,Recnik, Simon,Golic, Ljubo,Golobic, Amalija,Meden, Anton,Stanovnik, Branko,Svete, Jurij
, p. 2969 - 2988 (2007/10/03)
(S)-3-(Dimethylamino)methylidene-5-benzyltetramic acid derivatives 4a and 4b were prepared in three steps from N-protected (S)-3-phenylalanines 1a and 1b, respectively. Similarly, N-[N-(benzyloxycarbonyl)glycyl]grycine (1c) was transformed into the enamitione 4c. Acid-catalysed coupling of enaminones 4a-c with aliphatic, aromatic, and heteroaromatic primary amines 5-34 afforded the corresponding N(3′)-substituted 3-aminomethylidenetetramic acid derivatives 35-64 in 29-96% yields. Georg Thieme Verlag Stuttgart.
