112795-97-8

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 1-(aminocarbonyl)-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-, 1-methylethyl ester, (6S)-
• CAS NO: 112795-97-8
• Molecular Formula: C16H18N4O6
• Molecular Weight: 362.342
• Mol File: 112795-97-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 1-(aminocarbonyl)-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-, 1-methylethyl ester, (6S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 1-(aminocarbonyl)-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-, 1-methylethyl ester, (6S)-(112795-97-8)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 1-(aminocarbonyl)-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-, 1-methylethyl ester, (6S)-(112795-97-8)

Safety Data

• Hazardous Substances Data: 112795-97-8(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 123485-96-1 3,6-dihydro-4-methyl-6-(3-nitrophenyl)-2-0x0-1,5(2H)-pyrimidinedicarboxylic acid 5-(1-methylethyl) 1-(4-nitrophenyl) diester 
• 285136-73-4 Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 285136-74-5 Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 331947-79-6 Isopropyl 3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 285136-76-7 Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 131275-78-0 Isopropyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 3019-71-4 Trichloroacetyl isocyanate 
• 112795-99-0 <1(R),6S>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-oxo-1-<<(1-phenyl ethyl)amino>carbonyl>-5-pyrimidinecarboxylic acid, 1-methylethyl ester 

Relevant articles and documents

Synthesis and reactions of Biginelli-compounds. Part 23: Chemoenzymatic syntheses of enantiomerically pure 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Enantiomerically pure dihydropyrimidones (DHPMs) were prepared by lipase-catalyzed enzymatic resolution of two types of activated DHPM esters. In the first model series, pivaloyloxymethyl-activated DHPM C5-esters 10a-c were resolved on an analytical scale

Dihydropyrimidine calcium channel blockers. 3. 3-carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

In order to explain the potent antihypertensive activity of the modestly active (IC50 = 3.2 μM) dihydropyrimidine calcium channel blocker 5, we carried out drug metabolism studies in the rat and found 5 is metabolized to compounds 6-10. Two of