1128-91-2

Basic information

• Product Name: (E)-amino[(2-chlorobenzyl)imino]methanaminium chloride
• CAS NO: 1128-91-2
• Molecular Formula: C₈H₁₀ClN₃*ClH
• Molecular Weight: 220.099
• Mol File: 1128-91-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 332.6°C at 760 mmHg
• Flash Point: 154.9°C
• Vapor Pressure: 0.000144mmHg at 25°C
• CAS DataBase Reference: (E)-amino[(2-chlorobenzyl)imino]methanaminium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-amino[(2-chlorobenzyl)imino]methanaminium chloride(1128-91-2)
• EPA Substance Registry System: (E)-amino[(2-chlorobenzyl)imino]methanaminium chloride(1128-91-2)

Safety Data

• Hazardous Substances Data: 1128-91-2(Hazardous Substances Data)

Upstream product

• 89-97-4 2-CHLOROBENZYLAMINE 

Relevant articles and documents

Using N-substituted-2-amino-4,6-dimethoxypyrimidines in the synthesis of aliphatic guanidines

Abstract The use of 2-chloro-4,6-dimethoxypyrimdine as a tool for the syntheses of substituted guanidines is presented. This method, that we had previously shown to be very useful for aromatic amines, introduces an atom economical, cost effective and environmentally safe method for the installation of the guanidine functionality in aliphatic primary and secondary amines.

INHIBITION OF CELL PROLIFERATION

The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.