112883-41-7Relevant articles and documents
Syntheses of Thailandepsin B Pseudo-Natural Products: Access to New Highly Potent HDAC Inhibitors via Late-Stage Modification
Breit, Bernhard,Brosowsky, Jana,Herp, Daniel,Jung, Manfred,Keller, Manfred,Liebich, Amelie,Lutterbeck, Monika,Vogelmann, Anja
, p. 16241 - 16245 (2020)
New Thailandepsin B pseudo-natural products have been prepared. Our synthetic strategy offers the possibility to introduce varying warheads via late stage modification. Additionally, it gives access to the asymmetric branched allylic ester moiety of the natural product in a highly diastereoselective manner applying rhodium-catalyzed hydrooxycarbonylation. The newly developed pseudo-natural products are extremely potent and selective HDAC inhibitors. The non-proteinogenic amino acid d-norleucine was obtained enantioselectively by a recently developed method of rhodium-catalyzed hydroamination.
Novel peptides possessing a macrophage chemotactic activity
-
, (2008/06/13)
The present invention relates to physiologically active peptides and more particularly, to novel peptides having a specific amino acid sequence which possess a macrophage chemotactic activity.