112888-03-6

Basic information

• Product Name: N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid
• Synonyms: N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid
• CAS NO: 112888-03-6
• Molecular Weight: 468.466
• Mol File: 112888-03-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid(112888-03-6)
• EPA Substance Registry System: N - p-[ N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-methylamino]benzoyl-L-glutamic acid(112888-03-6)

Safety Data

• Hazardous Substances Data: 112888-03-6(Hazardous Substances Data)

Upstream product

• 92316-82-0 2,4-Dimethoxy-6-methylquinazoline 
• 112888-62-7 6-(Bromomethyl)-2,4-dimethoxyquinazoline 
• 2378-95-2 diethyl N-<4-(methylamino)benzoyl>-L-glutamate 
• 118111-78-7 (S)-2-{4-[(2,4-Dimethoxy-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid diethyl ester 

Relevant articles and documents

Anti-tumour agents

A quinazoline of the formula: STR1 wherein R1 is alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, aryl, aryloxy, arylalkyl, halogeno, hydroxy, mercapto, pyridylthio, pyrimidinylthio, or substituted alkyl or alkoxy; wherein R2 is hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl or alkanoyl; wherein Ar is phenylene, naphthylene or heterocyclene which is unsubstituted or bears one or more substituents and wherein R3 is such that R3 --NH2 is an amino acid; or a pharmaceutically-acceptable salt or ester thereof. The compounds possess anti-tumour activity.

Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position

The synthesis of 16 new N10-propargylquinazoline antifolates with methylamino, ethylamino, (2-aminoethyl)amino, [2-(dimethylamino)ethyl]amino, (2-hydroxyethyl)amino, (carboxymethyl)amino, dimethylamino, imidazol-1-yl, methoxy, ethoxy, phenoxy,