112898-03-0 Usage
Description
GLYCINE-1-13C-15N is a stable isotope-labeled analogue of glycine, a non-essential amino acid that plays a crucial role in human development. This labeled compound contains the stable isotopes carbon-13 (13C) and nitrogen-15 (15N) incorporated into its structure. Glycine serves as an inhibitory neurotransmitter in the spinal cord and acts as an allosteric regulator of NMDA receptors.
Uses
Used in Pharmaceutical Industry:
GLYCINE-1-13C-15N is used as a research tool for studying the metabolic pathways and functions of glycine in the human body. The incorporation of stable isotopes allows for easier tracking and analysis of glycine's role in various biological processes.
Used in Neuroscience Research:
GLYCINE-1-13C-15N is used as a tracer molecule in neuroscience research to investigate the role of glycine as an inhibitory neurotransmitter in the spinal cord. The stable isotopes enable researchers to monitor the compound's interactions with NMDA receptors and other neurotransmitter systems.
Used in Nutritional Studies:
GLYCINE-1-13C-15N can be utilized in nutritional studies to understand the absorption, distribution, metabolism, and excretion of glycine in the human body. This information can be valuable for developing targeted nutritional interventions and supplements.
Used in Agricultural Research:
In agricultural research, GLYCINE-1-13C-15N can be employed to study the biosynthesis and metabolism of glycine in plants and microorganisms. This knowledge can contribute to the development of crops with improved nutritional profiles and the optimization of microbial processes for the production of amino acids.
Used in Analytical Chemistry:
GLYCINE-1-13C-15N serves as an internal standard or reference material in analytical chemistry, particularly in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The stable isotopes provide a reliable reference for the accurate quantification and identification of glycine and its derivatives in complex samples.
Check Digit Verification of cas no
The CAS Registry Mumber 112898-03-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,8,9 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 112898-03:
(8*1)+(7*1)+(6*2)+(5*8)+(4*9)+(3*8)+(2*0)+(1*3)=130
130 % 10 = 0
So 112898-03-0 is a valid CAS Registry Number.
112898-03-0Relevant articles and documents
STABLE ISOTOPE-LABELED AMINO ACID, METHOD OF INTEGRATING THE SAME INTO TARGET PROTEIN, METHOD OF NMR STRUCTURAL ANALYSIS OF PROTEIN AND PROCESS FOR PRODUCING SITE-SELECTIVE STABLE ISOTOPE-LABELED FUMARIC ACID AND TARTARIC ACID
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Page 12, (2010/02/08)
The present invention provides a stable isotope-labeled amino acid which is at least one of amino acids constituting a protein and which has at least one of the following labeling patterns:(a) hydrogen atoms except at least one hydrogen atom in one or more methylene groups are deuterated,(b) hydrogen atoms in one of prochiral gem-methyl groups are completely deuterated,(c) hydrogen atoms in prochiral methyl groups are partially deuterated, and(d) all hydrogen atoms except one of them in methyl group are deuterated and hydrogen atoms in the aromatic ring are partially deuterated. With the stable isotope-labeled amino acid, the deuteration of protein can be attained without damaging the NMR sensitivity of remaining hydrogen nucleus and, in addition, the rapid, accurate analysis of NMR spectrum of a high-molecular protein which is beyond the limitation in the prior art and the determination of the stereo-structure can be performed at the same time.
