112913-97-0

Basic information

• Product Name: Morpholine, 2-(azidomethyl)-4-(phenylmethyl)-
• CAS NO: 112913-97-0
• Molecular Formula: C12H16N4O
• Molecular Weight: 232.285
• Mol File: 112913-97-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Morpholine, 2-(azidomethyl)-4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 2-(azidomethyl)-4-(phenylmethyl)-(112913-97-0)
• EPA Substance Registry System: Morpholine, 2-(azidomethyl)-4-(phenylmethyl)-(112913-97-0)

Safety Data

• Hazardous Substances Data: 112913-97-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 385814-36-8 4-(phenylmethyl)-2-morpholinemethanol methanesulfonate 
• 104-63-2 N-Benzylethanolamine 
• 40987-25-5 N-benzyl-2-chloromethylmorpholine 

Downstream Products

• 110859-47-7 (4-benzylmorpholin-2-yl)methanamine 
• 146944-34-5 (4-benzylmorpholin-2-ylmethyl)carbamic acid tert-butyl ester 
• 173341-02-1 N-(morpholin-2-ylmethyl)carbamic acid tert-butyl ester 
• 126645-58-7 N-(4-Benzyl-morpholin-2-ylmethyl)-3,5-dichloro-4-dimethylamino-2-hydroxy-benzamide 
• 126645-62-3 N-(4-Benzyl-morpholin-2-ylmethyl)-3,4,5-trimethoxy-benzamide 
• 126645-61-2 N-(4-Benzyl-morpholin-2-ylmethyl)-2,3,4,5,6-pentafluoro-benzamide 
• 112885-53-7 N-(4-Benzyl-morpholin-2-ylmethyl)-5-chloro-4-diethylamino-2-methoxy-benzamide 
• 112885-38-8 N-<(4-benzyl-2-morpholinyl)methyl>-3,4-(methylenedioxy)benzamide 
• 112885-51-5 N-(4-Benzyl-morpholin-2-ylmethyl)-5-chloro-4-dimethylamino-2-ethoxy-benzamide 
• 112885-55-9 N-<(4-benzyl-2-morpholinyl)methyl>-5-chloro-4-(dimethylamino)-2-methoxybenzamide 
• 112885-30-0 2,3-methylenedioxy-N-[(4-benzyl-2-morpholinyl)methyl]benzamide 
• 112885-49-1 N-(4-Benzyl-morpholin-2-ylmethyl)-5-chloro-4-dimethylamino-2-hydroxy-benzamide 
• 112885-58-2 N-(4-Benzyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-4-methylamino-benzamide 
• 112885-23-1 4-amino-N-<(4-benzyl-2-morpholinyl)methyl>-5-chloro-2-methoxybenzamide 

Relevant articles and documents

INDAZOLE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

The present invention relates to novel indazole compounds of the Formula (I), wherein, R1 is alkyl or cycloalkyl; (Formula II) including their stereoisomers and their pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-Hydroxytryptamine 4 (5-HT4) receptor agonists

Novel benzamides as selective and potent gastric prokinetic agents. 1. Synthesis and structure-activity relationships of N-[(2-morpholinyl)alkyl]benzamides

With the purpose of obtaining more potent and selective gastric prokinetic agents than metoclopramide (1), a new series of N-[(2-morpholinyl)alkyl]benzamides (17-52) were synthesized and their gastric prokinetic activity was evaluated by determining effect on the gastric emptying of phenol red semisolid meal and of resin pellets solid meal in rats and mice. The morpholinyl moiety was newly designed after consideration of the side-chain structure of cisapride (2) and produced the desired activity when coupled with the 4-amino-5-chloro-2-methoxybenzoyl group of both metoclopramide and cisapride. Modification of the substituents of the benzoyl group markedly influenced the activity. In particular, 4-amino-N-[benzyl-2-morpholinyl)methyl]-5-chloro-2-methoxybenzamide (17) and the 4-(dimethylamino) and 2-ethoxy analogues (25 and 29) or 17 showed potent and selective gastric prokinetic activity along with a weak dopamine D2 receptor antagonistic activity.