113-18-8 Usage
Description
ETHCHLORVYNOL CIV (0.7 ML) is a hypnotic and sedative medication, chemically defined as propargyl alcohol with methylene hydrogens substituted by ethyl and 2-chlorovinyl groups. It is used for the treatment of insomnia, particularly in cases where patients have an intolerance or allergy to more commonly used drugs. ETHCHLORVYNOL CIV (0.7 ML) is a clear, colorless oil and is commercially known by the brand name Placidyl (Abbott).
Uses
Used in Pharmaceutical Industry:
ETHCHLORVYNOL CIV (0.7 ML) is used as a hypnotic and sedative agent for the treatment of insomnia. It is particularly useful for patients who have an intolerance or allergy to more commonly used medications, providing an alternative option for managing sleep disorders.
Used in Controlled Substance Applications:
ETHCHLORVYNOL CIV (0.7 ML) is classified as a controlled substance due to its depressant effects. It is used in the management of sleep disorders and anxiety, offering relief to patients who may not respond well to other sedative or hypnotic medications.
Originator
Placidyl,Abbott,US,1965
Manufacturing Process
Acetylene was passed into a stirred solution of 3.05 grams (0.44 mol) of
lithium in 300 ml of liquid ammonia until the blue color exhibited by the
mixture had disappeared. Ethyl β-chlorovinyl ketone (47.4 grams; 0.40 mol)
dissolved in 50 ml dry ether was then added to the resulting solution of lithium acetylide over a period of 20 minutes, during which the color
deepened through yellow to reddish-brown. The mixture was stirred under
reflux maintained with a Dry Ice condenser for 2 hours. Thereafter, dry ether
(200 ml) was added and the ammonia was permitted to evaporate with
stirring overnight.The residue was poured into a slurry of ice and water containing 30 grams
(0.50 mol) of acetic acid. After separating the ether layer, the aqueous layer
was washed with two 200 milliliter portions of ether. The combined ether
extracts were washed with saturated sodium bicarbonate solution, dried over
anhydrous magnesium sulfate and evaporated in a stream of pure nitrogen.
Three successive distillations of the residue gave 46.3 grams (80.2% yield) of
a colorless liquid, boiling point 28.5° to 30°C at 0.1 mm Hg.
Therapeutic Function
Sedative, Hypnotic
Safety Profile
Poison by ingestion,
subcutaneous, intraperitoneal, and
intravenous routes. Human systemic effects
by ingestion: general anesthesia and
thrombocytopenia (reduction in the number
of blood platelets). Human effects on
newborn by an unspecified route: drug
dependency and Apgar score (condtion of
newborn). Experimental teratogenic and
reproductive effects. When heated to
decomposition it emits toxic fumes of Cl-.
Check Digit Verification of cas no
The CAS Registry Mumber 113-18-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 113-18:
(5*1)+(4*1)+(3*3)+(2*1)+(1*8)=28
28 % 10 = 8
So 113-18-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H9ClO/c1-3-7(9,4-2)5-6-8/h1,5-6,9H,4H2,2H3/b6-5-
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.