113010-10-9

Basic information

• Product Name: 3-<2-(dimethylamino)phenyl>-2,3-dihydropyrrolo<2,1-b>quinazolin-9(1H)-one; Vasicolinone
• CAS NO: 113010-10-9
• Molecular Weight: 305.379
• Mol File: 113010-10-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-<2-(dimethylamino)phenyl>-2,3-dihydropyrrolo<2,1-b>quinazolin-9(1H)-one; Vasicolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-<2-(dimethylamino)phenyl>-2,3-dihydropyrrolo<2,1-b>quinazolin-9(1H)-one; Vasicolinone(113010-10-9)
• EPA Substance Registry System: 3-<2-(dimethylamino)phenyl>-2,3-dihydropyrrolo<2,1-b>quinazolin-9(1H)-one; Vasicolinone(113010-10-9)

Safety Data

• Hazardous Substances Data: 113010-10-9(Hazardous Substances Data)

Upstream product

• 113010-09-6 N,N-dimethyl-2-(1,2,3,9-tetrahydropyrrolo<2,1-b>quinazolin-3-yl)benzenamine; Vasicoline 
• 50-00-0 formaldehyd 
• 142834-66-0 3-(2-aminophenyl)-1,2,3,9-tetrahydropyrrolo<2,1-b>quinazolin-9-one 

Relevant articles and documents

An Alternative Total Synthesis of Rutaecarpine and Vasicolinone Alkaloids

Rutaecarpine (6) and vasicolinone (9) alkaloids were alternatively prepared by Fischer indolization of 3-(phenylhydrazonomethyl)pyrroloquinazolinone (4) under thermal and acidic conditions, respectively.

A SHORT SYNTHESIS OF RUTECARPINE AND/OR VASICOLINONE FROM 2-CHLORO-3-(INDOL-3-YL)ETHYLQUINAZOLIN-4(3H)-ONE: EVIDENCE FOR THE PARTICIPATION OF THE SPIRO INTERMEDIATE

A new route to rutecarpine and/or vasicolinone from 2-chloro-4-quinazolone through an acid catalyzed cyclization of 2-chloro-3-indolylethylquinazolin-4-one has been developed and the mechanism of the cyclization reaction clarified.