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1130322-33-6

1130322-33-6

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1130322-33-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1130322-33-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,0,3,2 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1130322-33:
(9*1)+(8*1)+(7*3)+(6*0)+(5*3)+(4*2)+(3*2)+(2*3)+(1*3)=76
76 % 10 = 6
So 1130322-33-6 is a valid CAS Registry Number.

1130322-33-6Downstream Products

1130322-33-6Relevant articles and documents

II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides

Anilkumar, Gopinadhan N.,Selyutin, Oleg,Rosenblum, Stuart B.,Zeng, Qingbei,Jiang, Yueheng,Chan, Tin-Yau,Pu, Haiyan,Wang, Li,Bennett, Frank,Chen, Kevin X.,Lesburg, Charles A.,Duca, Jose,Gavalas, Stephen,Huang, Yuhua,Pinto, Patrick,Sannigrahi, Mousumi,Velazquez, Francisco,Venkatraman, Srikanth,Vibulbhan, Bancha,Agrawal, Sony,Ferrari, Eric,Jiang, Chuan-Kui,Huang,Shih, Neng-Yang,George Njoroge,Kozlowski, Joseph A.

scheme or table, p. 713 - 717 (2012/02/04)

Development of SAR at the C2 position of indole lead 1, a palm site inhibitor of HCV NS5B polymerase (NS5B IC50 = 0.053 μM, replicon EC50 = 4.8 μM), is described. Initial screening identified an acyl sulfonamide moiety as an isostere for the C2 carboxylic acid group. Further SAR investigation resulted in identification of acyl sufonamide analog 7q (NS5B IC50 = 0.039 μM, replicon EC50 = 0.011 μM) with >100-fold improved replicon activity.

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