113046-68-7

Basic information

• Product Name: 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-4-oxo-, ethyl ester
• CAS NO: 113046-68-7
• Molecular Formula: C24H23F2N3O3S
• Molecular Weight: 471.528
• Mol File: 113046-68-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-4-oxo-, ethyl ester(113046-68-7)
• EPA Substance Registry System: 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-4-oxo-, ethyl ester(113046-68-7)

Safety Data

• Hazardous Substances Data: 113046-68-7(Hazardous Substances Data)

Upstream product

• 3863-11-4 3,4-difluoroaniline 
• 113028-76-5 diethyl<<(3,4-difluorophenyl)amino><(methoxymethyl)-thio>methylene>malonate 
• 113028-77-6 ethyl 6,7-difluoro-4-hydroxy-2-<(methoxymethyl)thio>-quinoline-3-carboxylate 
• 144514-15-8 3,4-difluorophenyl dithiocarbamic acid triethylammonium 
• 84339-06-0 ethyl 7,6-difluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylate 
• 113028-75-4 3,4-difluorophenyl isothiocyanate 
• 6425-24-7 1-(dibromomethyl)-4-fluorobenzene 
• 109-01-3 1-methyl-piperazine 
• 144514-22-7 6,7-Difluoro-1-(4-fluoro-phenyl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 

Relevant articles and documents

STUDIES ON PYRIDONECARBOXYLIC ACIDS. 1. SYNTHESIS AND ANTIBACTERIAL EVALUATION OF 7-SUBSTITUTED-6-HALO-4-OXO-4H-THIAZETOQUINOLINE-3-CARBOXYLIC ACIDS

A series of thiazetoquinoline-3-carboxylic acids and their esters were prepared and evaluated for antibacterial activity.The derivatives with a hydrogen or methyl group at C-1, fluorine at C-6, and piperazinyl or 4-methyl-1-piperazinyl group at C-7 showed superior in vitro antibacterial activity, and the derivatives with 4-methyl-1-piperazinyl group at C-7 had potent in vivo activity.Compound 29a (NM394) showed excellent in vitro antibacterial activity and low toxicity but poor absorption from the gastrointestinal tract.Compound 29ee (NM441), an N- derivative of 29a, was found to possess a favorable pharmacokinetic profile and oral activity superior to that of ciprofloxacin in experimental animals.