113070-96-5

Basic information

• Product Name: 2-Propenal, 3-[4-(4-fluorophenyl)-2-(1-methylethyl)-5-phenyl-3-thienyl]-, (E)-
• CAS NO: 113070-96-5
• Molecular Formula: C22H19FOS
• Molecular Weight: 350.457
• Mol File: 113070-96-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenal, 3-[4-(4-fluorophenyl)-2-(1-methylethyl)-5-phenyl-3-thienyl]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenal, 3-[4-(4-fluorophenyl)-2-(1-methylethyl)-5-phenyl-3-thienyl]-, (E)-(113070-96-5)
• EPA Substance Registry System: 2-Propenal, 3-[4-(4-fluorophenyl)-2-(1-methylethyl)-5-phenyl-3-thienyl]-, (E)-(113070-96-5)

Safety Data

• Hazardous Substances Data: 113070-96-5(Hazardous Substances Data)

Upstream product

• 113070-94-3 4-(4-fluorophenyl)-2-isopropyl-5-phenyl-3-thiophenemethanol 
• 23521-49-5 (Z)-1-bromo-2-ethoxyethene 
• 113070-95-4 3-formyl-4-(4-fluorophenyl)-2-isopropyl-5-phenylthiophene 

Downstream Products

• 113070-97-6 7-[4-(4-fluorophenyl)-2-isopropyl-5-phenylthien-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid, ethyl ester 

Relevant articles and documents

Design and biological evaluation of a series of thiophene-based 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

A series of highly functionalized thiophene-based 3,5-dihydroxyheptenoic acid derivatives (10) were prepared from aldehydes 6 by homologation, aldol condensation with ethyl acetoacetate dianion and stereoselective β-hydroxyketone reduction. High levels of HMG-CoA reductase inhibitory activity have been found within the series. The most active analog in vitro was 10i whereas in vivo, 10e, 10i, 10m, 10n, 10o, and 10v were approximately equipotent.