1131041-72-9 Usage
Description
2-Amino-5-bromo-6-chloropyridin-3-ol is a heterocyclic organic compound with the molecular formula C5H4BrClN2O. It features a pyridine ring that is substituted with amino, bromo, chloro, and hydroxyl functional groups, making it a versatile building block for the synthesis of various biologically active compounds.
Used in Pharmaceutical Industry:
2-Amino-5-bromo-6-chloropyridin-3-ol is used as a key intermediate in the development of new drugs due to its unique structure and properties. It serves as a valuable component in the synthesis of various biologically active compounds, contributing to the advancement of pharmaceutical research and drug discovery.
Used in Agrochemicals:
In the agrochemical industry, 2-Amino-5-bromo-6-chloropyridin-3-ol may be utilized as a precursor or building block for the development of novel agrochemicals, such as pesticides or herbicides, that can help improve crop protection and yield.
Used in Materials Science:
2-Amino-5-bromo-6-chloropyridin-3-ol may also have potential applications in the field of materials science, where its unique structure and properties can be leveraged to create new materials with specific characteristics for various industrial applications.
It is important to handle 2-Amino-5-bromo-6-chloropyridin-3-ol with care and follow proper safety protocols due to its potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 1131041-72-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,1,0,4 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1131041-72:
(9*1)+(8*1)+(7*3)+(6*1)+(5*0)+(4*4)+(3*1)+(2*7)+(1*2)=79
79 % 10 = 9
So 1131041-72-9 is a valid CAS Registry Number.
InChI:InChI=1S/C5H4BrClN2O/c6-2-1-3(10)5(8)9-4(2)7/h1,10H,(H2,8,9)
1131041-72-9Relevant articles and documents
Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines
Lin, Hong,Yamashita, Dennis S.,Xie, Ren,Zeng, Jin,Wang, Wenyong,Leber, Jack,Safonov, Igor G.,Verma, Sharad,Li, Mei,LaFrance, Louis,Venslavsky, Joseph,Takata, Dennis,Luengo, Juan I.,Kahana, Jason A.,Zhang, Shuyun,Robell, Kimberly A.,Levy, Dana,Kumar, Rakesh,Choudhry, Anthony E.,Schaber, Michael,Lai, Zhihong,Brown, Barry S.,Donovan, Brian T.,Minthorn, Elisabeth A.,Brown, Kristin K.,Heerding, Dirk A.
scheme or table, p. 684 - 688 (2010/06/14)
The synthesis and evaluation of tetrasubstituted aminopyridines, bearing novel azaindazole hinge binders, as potent AKT inhibitors are described. Compound 14c was identified as a potent AKT inhibitor that demonstrated reduced CYP450 inhibition and an improved developability profile compared to those of previously described trisubstituted pyridines. It also displayed dose-dependent inhibition of both phosphorylation of GSK3β and tumor growth in a BT474 tumor xenograft model in mice.
INHIBITORS OF AKT ACTIVITY
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Page/Page column 9; 37-38, (2009/04/25)
Invented are novel substituted pyridine compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
