1131410-85-9Relevant articles and documents
TRIAZOLOPYRIDINE COMPOUNDS USEFUL AS PESTICIDES
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, (2022/01/12)
The present disclosure provides a novel triazolopyridine compound as represented by formula (I) or a salt thereof that controls pests: wherein, R1 and R3 independently represent hydrogen, or the like; R2 represents C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, or the like; R4, R5, R7, and R8 independently represent hydrogen, halogen, or the like; R6 represents C1-C6 haloalkoxy, or the like; and Z represents an oxygen atom, a sulfur atom, SO, or SO2.
NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER
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, (2015/01/09)
The present invention relates to novel compounds showing an inhibitory effect on Mps-1 kinase, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
East, Stephen P.,White, Clara Bantry,Barker, Oliver,Barker, Stephanie,Bennett, James,Brown, David,Boyd, E. Andrew,Brennan, Christopher,Chowdhury, Chandana,Collins, Ian,Convers-Reignier, Emmanuelle,Dymock, Brian W.,Fletcher, Rowena,Haydon, David J.,Gardiner, Mihaly,Hatcher, Stuart,Ingram, Peter,Lancett, Paul,Mortenson, Paul,Papadopoulos, Konstantinos,Smee, Carol,Thomaides-Brears, Helena B.,Tye, Heather,Workman, James,Czaplewski, Lloyd G.
scheme or table, p. 894 - 899 (2009/08/15)
The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported. The most potent scaffold was selected for optimization leading to a series with potent Gram-positive antibacterial activity and a low resistance frequency.