113171-12-3

Basic information

• Product Name: 1H-1,2,4-Triazole-3-sulfonamide, 5-amino-N-(2,6-difluorophenyl)-
• CAS NO: 113171-12-3
• Molecular Formula: C8H7F2N5O2S
• Molecular Weight: 275.239
• Mol File: 113171-12-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazole-3-sulfonamide, 5-amino-N-(2,6-difluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole-3-sulfonamide, 5-amino-N-(2,6-difluorophenyl)-(113171-12-3)
• EPA Substance Registry System: 1H-1,2,4-Triazole-3-sulfonamide, 5-amino-N-(2,6-difluorophenyl)-(113171-12-3)

Safety Data

• Hazardous Substances Data: 113171-12-3(Hazardous Substances Data)

Usage

Molecular weight

281.25 g/mol

Structure

Amino group and sulfonamide group attached to a triazole ring

Fluorine atoms

Two fluorine atoms are attached to the phenyl ring

Uses

Potential antifungal and antitumor agent, ability to inhibit the growth of cancer cells and fungi

Versatility

Unique structure and properties may have potential applications in other areas of pharmacology and biochemistry.

Upstream product

• 129879-84-1 5-Amino-3-chlorosulfonyl-1,2,4-triazole 
• 5509-65-9 2,6-difluoroaniline 

Downstream Products

• 98967-40-9 N-(2,6-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide 

Relevant articles and documents

Preparation of 5-acylamino-1,2,4-triazole-3-sulfonamides

5-Acylamino-1,2,4-triazole-3-sulfonamides, which are useful intermediates for the preparation of 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide herbicides are prepared from 5-amino-3-mercapto-1,2,4-triazole by sequential acylation to 5-acylamino-3-mercapto-1,2,4-triazoles, chlorination to 5-acylamino-3-chlorosulfonyl-1,2,4-triazoles, and condensation with substituted anilines to 5-acylamino-1,2,4-triazole-3-sulfonamides. 5-Acylamino-3-chlorosulfonyl-1,2,4-triazole compounds are key intermediates in the process.

Process for the preparation of 5-amino-3-chlorosulfonyl-1,2,4-triazole

5-Amino-3-chlorosulfonyl-1,2,4-triazole is prepared by the chlor-oxidation of 5-amino-3-mercapto-1,2,4-triazole. The process is characterized by the preformation of disulfide from the mercaptan prior to treatment with chlorine. The 5-amino-3-chlorosulfonyl-1,2,4-triazole reaction mixture can be directly reacted with substituted anilines to prepare N-(3-(((aryl)amino)sulfonyl)-1H-1,2,4-triazol-5-yl)amines which are useful intermediates for the manufacture of herbicides.