1131890-88-4

Basic information

• Product Name: 2,5-dimethyl-1-phenyl-1H-indole
• Synonyms: 2,5-dimethyl-1-phenyl-1H-indole
• CAS NO: 1131890-88-4
• Molecular Weight: 221.302
• Mol File: 1131890-88-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,5-dimethyl-1-phenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethyl-1-phenyl-1H-indole(1131890-88-4)
• EPA Substance Registry System: 2,5-dimethyl-1-phenyl-1H-indole(1131890-88-4)

Safety Data

• Hazardous Substances Data: 1131890-88-4(Hazardous Substances Data)

Upstream product

• 1196-79-8 2,5-Dimethyl-1H-indole 
• 591-50-4 iodobenzene 
• 1131890-85-1 2-chloro-5-methylphenyl trifluoromethanesulfonate 
• 1124-52-3 N-(propan-2-ylidene)aniline 

Relevant articles and documents

Transition-Metal-Free C3 Arylation of Indoles with Aryl Halides

We report an unprecedented transition metal-free coupling of indoles with aryl halides. The reaction is promoted by KOtBu and is regioselective for C3 over N. The use of degassed solvents devoid of oxygen is necessary for the success of the transformation. Preliminary studies implicate a hybrid mechanism that involves both aryne intermediates and non-propagative radical processes. Electron transfer is also a distinct possibility. These conclusions were substantiated by EPR data, isotopic labeling studies, and the use of radical scavengers and electron transfer inhibitors.