1132669-91-0

Basic information

• Product Name: 4-Chloro-2-forMylphenylboronic acid, pinacol ester
• Synonyms: 4-Chloro-2-forMylphenylboronic acid, pinacol ester
• CAS NO: 1132669-91-0
• Molecular Formula: C₁₃H₁₆BClO₃
• Molecular Weight: 284.54362
• Mol File: 1132669-91-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 365.7±32.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4-Chloro-2-forMylphenylboronic acid, pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-forMylphenylboronic acid, pinacol ester(1132669-91-0)
• EPA Substance Registry System: 4-Chloro-2-forMylphenylboronic acid, pinacol ester(1132669-91-0)

Safety Data

• Hazardous Substances Data: 1132669-91-0(Hazardous Substances Data)

Usage

Uses

4-Chloro-2-formylphenylboronic acid, pinacol ester

Upstream product

• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 913835-76-4 4-chloro-2-aldehyde phenylboronic acid 

Relevant articles and documents

Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases

The production of β-lactamases represents the main cause of resistance to clinically important β-lactam antibiotics. Boron containing compounds have been demonstrated as promising broad-spectrum β-lactamase inhibitors to combat β-lactam resistance. Here we report a series of 3-aryl substituted benzoxaborole derivatives, which manifested broad-spectrum inhibition to representative serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs). The most potent inhibitor 9f displayed an IC50 value of 86 nM to KPC-2 SBL and micromolar inhibitory activity towards other tested enzymes. Cell-based assays further revealed that 9f was able to significantly reduce the MICs of meropenem in clinically isolated KPC-2-producing bacterial strains and it showed no apparent toxicity in HEK293T cells.