1132709-15-9 Usage
Description
((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid is a complex organic compound with a unique molecular structure that features a boronic acid group, a chiral center, and a pyrazine-2-carboxamide moiety. ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid exhibits specific stereochemistry and functional groups that make it a promising candidate for various applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butronic acid is used as a chiral building block for the synthesis of enantioselective drugs. Its unique molecular structure and functional groups enable the development of new drugs with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
Used in Chemical Synthesis:
((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butronic acid is used as a versatile intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its boronic acid group allows for selective and efficient coupling reactions, while its chiral center and pyrazine-2-carboxamide moiety provide opportunities for the creation of novel molecular architectures.
Used in Proteasome Inhibition:
((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butronic acid is used as a proteasome inhibitor, targeting the ubiquitin-proteasome pathway. ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid has the potential to be developed into a therapeutic agent for the treatment of various diseases, including cancer, by modulating the activity of the 26S proteasome, a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Its chiral center and unique functional groups may contribute to its selectivity and potency as a proteasome inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 1132709-15-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,2,7,0 and 9 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1132709-15:
(9*1)+(8*1)+(7*3)+(6*2)+(5*7)+(4*0)+(3*9)+(2*1)+(1*5)=119
119 % 10 = 9
So 1132709-15-9 is a valid CAS Registry Number.
1132709-15-9Relevant articles and documents
Structure-Based Design of Selective LONP1 Inhibitors for Probing in Vitro Biology
Kingsley, Laura J.,He, Xiaohui,McNeill, Matthew,Nelson, John,Nikulin, Victor,Ma, Zhiwei,Lu, Wenshuo,Zhou, Vicki W.,Manuia, Mari,Kreusch, Andreas,Gao, Mu-Yun,Witmer, Darbi,Vaillancourt, Mei-Ting,Lu, Min,Greenblatt, Sarah,Lee, Christian,Vashisht, Ajay,Bender, Steven,Spraggon, Glen,Michellys, Pierre-Yves,Jia, Yong,Haling, Jacob R.,Lelais, Gérald
, p. 4857 - 4869 (2021/05/07)
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Despite the importance of LONP1 in human biology and disease, very few LONP1 inhibitors have been described in the literature. Herein, we report the development of selective boronic acid-based LONP1 inhibitors using structure-based drug design as well as the first structures of human LONP1 bound to various inhibitors. Our efforts led to several nanomolar LONP1 inhibitors with little to no activity against the 20S proteasome that serve as tool compounds to investigate LONP1 biology.
