1132709-16-0 Usage
Description
Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]is a complex organic compound with a unique structure that features a boron atom bonded to a variety of carbon and nitrogen-containing groups. This molecule has potential applications in various fields due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]is used as a pharmaceutical intermediate for the development of novel drugs targeting specific biological pathways. Its unique structure allows for the design of molecules with high specificity and affinity for their target proteins, making it a valuable tool in drug discovery and development.
Used in Chemical Synthesis:
In the field of chemical synthesis, Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]can be used as a building block or a reagent in the synthesis of complex organic molecules. Its ability to form stable bonds with a variety of other molecules makes it a versatile component in the creation of new chemical entities.
Used in Materials Science:
Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]may also find applications in materials science, where its unique structure and reactivity can be harnessed to create new materials with specific properties. These materials could have potential uses in various industries, such as electronics, energy, or biomedical applications.
Used in Research and Development:
Due to its unique structure and potential applications, Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]is also used in research and development settings. Scientists and researchers can explore its properties and reactivity to gain a better understanding of its potential uses and to develop new applications for this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 1132709-16-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,2,7,0 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1132709-16:
(9*1)+(8*1)+(7*3)+(6*2)+(5*7)+(4*0)+(3*9)+(2*1)+(1*6)=120
120 % 10 = 0
So 1132709-16-0 is a valid CAS Registry Number.
1132709-16-0Relevant articles and documents
α-boryl isocyanides enable facile preparation of bioactive boropeptides
Zajdlik, Adam,Wang, Zezhou,Hickey, Jennifer L.,Aman, Ahmed,Schimmer, Aaron D.,Yudin, Andrei K.
, p. 8411 - 8415 (2013)
Entry to bioactive boropeptides: MIDA-containing α-boryl isocyanides are isolable molecules which allow one-step access to boroalkyl-functionalized heterocycles as well as biologically active boropeptides through a multicomponent approach. Among these derivatives are 6-boromorpholinones, novel borocycles with nanomolar IC50 values for 20S proteasome inhibition. MIDA=N-methyliminodiacetyl. Copyright
Asymmetric Synthesis of α-Aminoboronates via Rhodium-Catalyzed Enantioselective C(sp3)-H Borylation
Reyes, Ronald L.,Sato, Miyu,Iwai, Tomohiro,Sawamura, Masaya
supporting information, p. 589 - 597 (2020/01/22)
α-Aminoboronic acids, isostructural boron analogues of α-amino acids, have received much attention because of the important biomedical applications implicated for compounds containing this structure. Additionally, the inherent versatility of α-aminoboronic acids as synthetic intermediates through diverse carbon-boron bond transformations makes the efficient synthesis of these compounds highly desirable. Here, we present a Rh-monophosphite chiral catalytic system that enables a highly efficient enantioselective borylation of N-adjacent C(sp3)-H bonds for a range of substrate classes including 2-(N-alkylamino)heteroaryls and N-alkanoyl- or aroyl-based secondary or tertiary amides, some of which are pharmaceutical agents or related compounds. Various stereospecific transformations of the enantioenriched α-aminoboronates, including Suzuki-Miyaura coupling with aryl halides and the Rh-catalyzed reaction with an isocyanate derivative of α-amino acid, affording a new peptide chain elongation method, have been demonstrated. As a highlight of this work, the borylation protocol was successfully applied to the catalyst-controlled site-selective and stereoselective C(sp3)-H borylation of an unprotected dipeptidic compound, allowing remarkably streamlined synthesis of the anti-cancer drug molecule bortezomib and offering a straightforward route for the synthesis of privileged molecular architectures.
PROCESS FOR PREPARING BORTEZOMIB, INTERMEDIATES, AND CRYSTALLINE FORMS THEREOF
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Paragraph 0043, (2020/05/29)
The present disclosure provides a process for preparing Bortezomib, intermediates, and crystalline forms thereof.
