113293-71-3

Basic information

• Product Name: (6-AMINO-3-PYRIDINYL)METHANOL
• Synonyms: 6-AMINO-3-HYDROXYMETHYLPYRIDINE;(6-AMINO-3-PYRIDINYL)METHANOL;(6-AMINO-PYRIDIN-3-YL)-METHANOL;2-Amino-5-(hydroxymethyl)pyridine;2-Amino-5-pyridinemethanol;2-Amino-5-(hydroxymethyl)pyridine 97%;3-Pyridinemethanol,6-amino-(9CI);2-AMINO-5-PYRIDINEMETHANOL(2-AMINO-5-HYDROXYMETHYLPYRIDINE)
• CAS NO: 113293-71-3
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14
• Product Categories: PYRIDINE;pharmacetical;Furans
• Mol File: 113293-71-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 120 °C
• Boiling Point: 320.211 °C at 760 mmHg
• Flash Point: 147.459 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 0.000134mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.61±0.10(Predicted)
• Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
• CAS DataBase Reference: (6-AMINO-3-PYRIDINYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (6-AMINO-3-PYRIDINYL)METHANOL(113293-71-3)
• EPA Substance Registry System: (6-AMINO-3-PYRIDINYL)METHANOL(113293-71-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38-20/21/22
• Safety Statements: 22-26-36/37/39
• RIDADR: 2811
• Hazardous Substances Data: 113293-71-3(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow solid

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

InChI:InChI=1/C6H8N2O/c7-6-2-1-5(4-9)3-8-6/h1-3,9H,4H2,(H2,7,8)

Upstream product

• 39658-41-8 ethyl-6-amino-nicotinate 
• 36052-24-1 methyl 6-aminonicotinoate 
• 329-89-5 6-aminonicotinic amide 
• 866561-42-4 acetic acid 6-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pyridin-3-ylmethyl ester 
• 3167-49-5 6-aminonicotinic acid 

Downstream Products

• 132213-07-1 6-(hydroxymethyl)imidazo[1,2-a]pyridine 
• 132213-03-7 imidazo<1,2-a>pyridin-6-ylmethylamine 
• 230617-81-9 2-amino-5-pyridylmethyl chloride 
• 929898-44-2 {2-[4-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-phenyl]-imidazo[1,2-a]pyridin-6-yl}-methanol 
• 1034309-74-4 5-(tert-butyldiphenylsilanyloxymethyl)pyridin-2-ylamine 
• 938461-34-8 {2-[4-(1,3-oxazol-5-yl)phenyl]imidazo[1,2-a]pyridin-6-yl}methanol 
• 1227486-25-0 [6-(tritylamino)pyridin-3-yl]methanol 
• 1227486-26-1 5-[(dimethylamino)methyl]-N-tritylpyridin-2-amine 
• 1227486-27-2 5-(methoxymethyl)-N-tritylpyridin-2-amine 
• 1018447-30-7 phenyl 5-((tert-butyldimethylsilyloxy)methyl)pyridin-2-ylcarbamate 
• 1419604-39-9 1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-((tert-butyldimethylsilyloxy)methyl)pyridin-2-yl)urea 
• 1419601-14-1 1-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-3-(5-(hydroxymethyl)pyridin-2-yl)urea 
• 69879-22-7 6-amino-3-pyridinecarbaldehyde 
• 1180132-17-5 5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine 

Relevant articles and documents

Photoswitchable Inhibitor of the Calcium Channel TRPV6

Herein we report the first photoswitchable inhibitor of Transient Receptor Potential Vanilloid 6 (TRPV6), a selective calcium channel involved in a number of diseases and in cancer progression. By surveying analogs of a previously reported TRPV6 inhibitor appended with a phenyl-diazo group, we identified a compound switching between a weak TRPV6 inhibitor in its dark, E-diazo stereoisomer (Z/E = 3:97, IC50 ? 10 μM) and a potent inhibitor as the Z-diazo stereoisomer accessible reversibly by UV irradiation at λ = 365 nm (Z/E = 3:1, IC50 = 1.7 ± 0.4 μM), thereby allowing precise spatiotemporal control of inhibition. This new tool compound should be useful to deepen our understanding of TRPV6.

CRYSTAL FORM, SALT TYPE OF SUBSTITUTED 2-HYDRO-PYRAZOLE DERIVATIVE AND PREPARATION METHOD THEREFOR

A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.

SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.