113310-88-6 Usage
Description
(S)-3,5-DICHLORO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2,6-DIHYDROXY-BENZAMIDE HYDROBROMIDE is a complex organic compound with a hydrobromide salt form. It features a benzamide core structure, with two hydroxyl groups at the 2,6 positions, and a 3,5-dichlorinated aromatic ring. The molecule also contains a 1-ethyl-2-pyrrolidinylmethyl group attached to the amide nitrogen, which may contribute to its potential interactions with biological targets. This colorless to yellowish solid is characterized by its unique chemical properties and structural features.
Uses
Used in Pharmaceutical Industry:
(S)-3,5-DICHLORO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2,6-DIHYDROXY-BENZAMIDE HYDROBROMIDE is used as an intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its specific chemical structure allows it to be a key component in the development of new drugs targeting specific biological pathways or receptors.
Used in Radioligand Synthesis:
(S)-3,5-DICHLORO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2,6-DIHYDROXY-BENZAMIDE HYDROBROMIDE is used for the improved synthesis of radioligands, such as PET dopamine D2 receptors radioligand. This application is particularly relevant in the field of medical imaging, where it aids in the visualization and study of dopamine receptor activity in the brain, which is crucial for understanding and diagnosing neurological disorders.
Used in Chemical Research:
As a complex organic molecule, (S)-3,5-DICHLORO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2,6-DIHYDROXY-BENZAMIDE HYDROBROMIDE is also used in chemical research to explore its potential reactivity, stability, and interactions with other molecules. This can lead to a better understanding of its properties and possible applications in various fields, including materials science and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 113310-88-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,3,1 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 113310-88:
(8*1)+(7*1)+(6*3)+(5*3)+(4*1)+(3*0)+(2*8)+(1*8)=76
76 % 10 = 6
So 113310-88-6 is a valid CAS Registry Number.
113310-88-6Relevant articles and documents
An improved synthesis of PET dopamine D2 receptors radioligand [11c]raclopride
Fei, Xiangshu,Mock, Bruce H.,DeGrado, Timothy R.,Wang, Ji-Quari,Glick-Wilson, Barbara E.,Sullivan, Michael L.,Hutchins, Gary D.,Zheng, Qi-Huang
, p. 1897 - 1907 (2004)
An improved synthesis of [11C]raclopride is reported. The precursor desmethyl-raclopride was synthesized from 3,5-dichloro-2,6-dimethoxybenzoic acid and (S)-(-)-2-aminoethyl-1-ethylpyrrolidine via a straight-forward, four-step synthetic approac
Synthesis of ω-Fluoroalkoxy and Alkoxy Derivatives of Raclopride: Evaluation as Radioligands for PET study of Cerebral Dopamine D2 Receptors
Banks, William R.,Moerlein, Stephen M.,Parkinson, David,Welch, Michael J.
, p. 150 - 173 (2007/10/03)
A series of analogues of the dopamine D2 receptor antagonist raclopride were evaluated as radiopharmaceuticals for positron emission tomography (PET). In vitro assays indicate that the D2 affinity of the ligands are descreased by replacement of the 2-methoxy group of raclopride with ω-fluoroalkoxy substituents, and increased by removal of the 6-hydroxy substituent. The 2-fluoroethoxy derivative of deshydroxy raclopride, [(S)-2-[(3,5)-dichloro-2-(2'-fluoroethoxy)benzamido)-methyl]-1-ethylpyrrolidine], exhibited a D2 affinity (Ki = 12nM) close to that of raclopride itself (Ki = 9.5 nM). A one-step radiosynthesis of the fluorine-18 labeled analogue of this ligand with specific radioactivity > 2 Ci/μmol and 35 percent radiochemical yield (decay-corrected) was developed; there was poor receptor-specific localization of this radioligand in vivo in rats, however. These results underscore the inadequacy of in vitro receptor assays as the sole screening test for PET radiopharmaceuticals. Future development of this series of ligands should emphasize placement of the fluorine-18 label at an aromatic site remote from the intramolecular hydrogen-bonding sites necessary for receptor-active conformations