113333-93-0

Basic information

• Product Name: 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
• Synonyms: 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
• CAS NO: 113333-93-0
• Molecular Formula: C₁₆H₁₂FNO₃
• Molecular Weight: 285.2697832
• Mol File: 113333-93-0.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one(113333-93-0)
• EPA Substance Registry System: 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one(113333-93-0)

Safety Data

• Hazardous Substances Data: 113333-93-0(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 80646-00-0 3-(4-fluorophenyl)-3-oxopropanoic acid 
• 62-53-3 aniline 
• 42366-35-8 hydroxyimino-N-phenylacetamide 

Downstream Products

• 98711-39-8 1,3-Dihydro-3-<2-(4-fluorophenyl)-2-oxoethylidene>indol-2(1H)-one 
• 98711-39-8 1,3-dihydro-3-<2-(4-fluorophenyl)-2-oxoethylidene>-2H-indol-2-one 
• 113333-94-1 2-(4-fluorobenzoyl)-spiro-2'(1'H)-one 
• 134277-23-9 2',4'-dihydro-5'-(4-fluorophenyl)spiro<3H-indol-3,3'-<3H>pyrazol>-2(1H)-one 
• 134277-34-2 2',4'-dihydro-5'-(4-fluorophenyl)-2'-phenylspiro<3H-indol-3,3'-(3H)pyrazol>-2(1H)-one 
• 134277-35-3 2',4'-dihydro-5'-(4-fluorophenyl)-2'-pentafluorophenylspiro<3H-indol-3,3'-<3H>pyrazol>-2(1H)-one 
• 139715-36-9 1,3-dihydro-3-<2(4-fluorophenyl)-2-hydrazoethylidene>-2H-indol-2-one 
• 139715-37-0 3-(4-fluorophenyl)-1-phenyl-9H-pyridazino<3,4-b>indole 
• 97311-55-2 1,3-dihydro-3-<2-(4-fluorophenyl)-2-(phenylhydrazono)-ethylidene>-2H-indol-2-one 
• 139715-38-1 3-(4-fluorophenyl)-1-pentafluorophenyl-9H-pyridazino<3,4-b>indole 
• 1408005-91-3 6-(4-fluorophenyl)-1,3-dimethyl-5-(2-oxoindolin-3-yl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione 
• 1243101-19-0 6-(4-fluorophenyl)-5-(2-oxoindolin-3-yl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione 
• 1622878-54-9 3-(4-fluorophenyl)-9-acetyl-pyridazino[3,4-b]indole 

Relevant articles and documents

Hit optimization studies of 3-hydroxy-indolin-2-one analogs as potential anti-HIV-1 agents

In the current study, twenty-two compounds based upon 3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one nucleus were designed, synthesized and in vitro evaluated for HIV-1 RT inhibition and anti-HIV-1 activity. Compounds 3d, 5c and 5e demonstrated encouragin

"on Water" Catalytic Aldol Reaction between Isatins and Acetophenones: Interfacial Hydrogen Bonding and Enamine Mechanism

"On water" catalytic aldol reaction catalyzed by polyetheramine (D230) has been developed for easy access to 3-substituted 3-hydroxyindolin-2-ones through the reaction between various substituted isatins and acetophenones/cyclic ketones in high yields under room temperature. Systematic mechanism investigation uncovers the secret for the on water catalytic aldol reaction: comparison of the heterogeneous and homogeneous reaction circumstances with yields of 95 and 20%, respectively, indicates the on-water reaction dominating; interfacial hydrogen bonding between isatin with H2O is tested based on the downfield shift of the C2 and C3's 13C NMR signals when water was added to the CDCl3 solution of isatin; Lewis base polyetheramine D230 catalyzes the aldol reaction via the enamine mechanism verified by in situ NMR and ESI-MS analysis.

Green catalytic synthesis method of isatin derivative

The invention discloses a green catalytic synthesis method of isatin derivative. The method comprises the following steps: adopting isatin compound and ketone containing alpha-hydrogen as raw materials, adopting water as a solvent to perform Aldol reactio