Cas 1133434-20-4,(+)-1,4-dimethyl-3-(4-nitrophenyl)piperazin-2-one

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Check Digit Verification of cas no

The CAS Registry Mumber 1133434-20-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,3,4,3 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1133434-20:
(9*1)+(8*1)+(7*3)+(6*3)+(5*4)+(4*3)+(3*4)+(2*2)+(1*0)=104
104 % 10 = 4
So 1133434-20-4 is a valid CAS Registry Number.

1133434-20-4Upstream product

1133434-20-4Downstream Products

1133433-98-3 5-bromo-3-(4-((S)-1,4-dimethyl-3-oxopiperazin-2yl)phenylamino)-1-methylpyrazin-2(1H)-one

1133434-20-4Relevant articles and documents

Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834

Young, Wendy B.,Barbosa, James,Blomgren, Peter,Bremer, Meire C.,Crawford, James J.,Dambach, Donna,Gallion, Steve,Hymowitz, Sarah G.,Kropf, Jeffrey E.,Lee, Seung H.,Liu, Lichuan,Lubach, Joseph W.,Macaluso, Jen,Maciejewski, Pat,Maurer, Brigitte,Mitchell, Scott A.,Ortwine, Daniel F.,Di Paolo, Julie,Reif, Karin,Scheerens, Heleen,Schmitt, Aaron,Sowell, C. Gregory,Wang, Xiaojing,Wong, Harvey,Xiong, Jin-Ming,Xu, Jianjun,Zhao, Zhongdong,Currie, Kevin S.

, p. 1333 - 1337 (2015)

SAR studies focused on improving the pharmacokinetic (PK) properties of the previously reported potent and selective Btk inhibitor CGI-1746 (1) resulted in the clinical candidate GDC-0834 (2), which retained the potency and selectivity of CGI-1746, but wi

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1133434-20-4