113411-59-9

Basic information

• Product Name: 1-Benzyl-4-(2-methoxyphenyl)tetrahydropyridine
• Synonyms: 1-BENZYL-4-(2-METHOXYPHENYL)TETRAHYDROPYRIDINE
• CAS NO: 113411-59-9
• Molecular Formula: C₁₉H₂₁NO
• Molecular Weight: 279.38
• Mol File: 113411-59-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 416.697 °C at 760 mmHg
• Flash Point: 122.284 °C
• Appearance: /
• Density: 1.094 g/cm³
• CAS DataBase Reference: 1-Benzyl-4-(2-methoxyphenyl)tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-(2-methoxyphenyl)tetrahydropyridine(113411-59-9)
• EPA Substance Registry System: 1-Benzyl-4-(2-methoxyphenyl)tetrahydropyridine(113411-59-9)

Safety Data

• Hazardous Substances Data: 113411-59-9(Hazardous Substances Data)

Usage

General Description

1-Benzyl-4-(2-methoxyphenyl)tetrahydropyridine, also known as MPTP, is a chemical compound that is commonly used in the laboratory to study neurotoxicity and Parkinson's disease. MPTP is known to cause damage to certain cells in the brain, specifically the dopaminergic cells in the substantia nigra, leading to symptoms similar to those of Parkinson's disease. MPTP is often used to induce Parkinson's-like symptoms in animal models for research purposes. 1-Benzyl-4-(2-methoxyphenyl)tetrahydropyridine is highly toxic and should be handled with care in a laboratory setting. Its neurotoxic effects have led to significant research into the underlying mechanisms of Parkinson's disease and potential therapeutic strategies for the condition.

Upstream product

• 113411-58-8 1-Benzyl-4-hydroxy-4-(2-methoxyphenyl)piperidine hydrochloride 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 130305-58-7 1-benzyl-4-(2-methoxyphenyl)piperidin-4-ol 
• 936231-01-5 1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine hydrochloride 
• 529-28-2 4-iodoanisol 
• 578-57-4 2-bromoanisole 

Downstream Products

• 113411-60-2 trans-1-Benzyl-4-(2-methoxyphenyl)-3-piperidinol 
• 744220-48-2 5-(2-methoxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonane 
• 744220-49-3 1-benzyl-5-(2-methoxyphenyl)-2-azabicyclo[3.3.1]nonane 
• 113447-03-3 2-Benzyl-1,2,3,4-tetrahydrobenzofuro<2,3-c>pyridine 
• 113411-61-3 1-Benzyl-4-(2-methoxyphenyl)-3-piperidone 
• 907566-91-0 1-benzyl-4-(2-methoxyphenyl)piperidin-3-ol 
• 58333-75-8 4-(2-methoxyphenyl)piperidine 
• 82212-04-2 1,2,3,4,5,6-hexahydro-4-(2-methoxyphenyl)pyridine hydrochloride 

Relevant articles and documents

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.

Synthesis of 4-arylpiperidines from 1-benzyl-4-piperidone: Application of the shapiro reaction and alkenylsilane cross-coupling

Equation Presented 1-Benzyl-3,4-unsaturated-4-piperidinyl benzyldimethylsilane has been prepared and observed to readily undergo palladium-catalyzed cross-coupling reactions with a variety of aryl iodides and aryl bromides to generate 3,4-unsaturated 4-arylpiperidines, often at ambient temperature.

A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.

The opioid receptor binding affinities of N-methyl- and N-phenethyl-5-phenylmorphans with a meta-hydroxy substituent [3-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1a), and 3-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1b)] were compared with the