113418-56-7

Basic information

• Product Name: 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione
• Synonyms: 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione;Wy-49051
• CAS NO: 113418-56-7
• Molecular Formula: C28H33N5O3
• Molecular Weight: 487.59332
• Mol File: 113418-56-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 672.7±65.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 8.32±0.10(Predicted)
• CAS DataBase Reference: 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione(113418-56-7)
• EPA Substance Registry System: 3,7-Dihydro-1,3-dimethyl-7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-1H-purine-2,6-dione(113418-56-7)

Safety Data

• Hazardous Substances Data: 113418-56-7(Hazardous Substances Data)

Upstream product

• 23146-06-7 7-(3-bromo-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 58-55-9 theophylline 
• 776-74-9 Bromodiphenylmethane 
• 113418-64-7 7-[3-(4-hydroxy)-1-piperidinyl]propyl-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione 

Relevant articles and documents

New antihistamines: Substituted piperazine and piperidine derivatives as novel H1-antagonists

Structural manipulation of polycyclic piperazinyl imide serotonergic agents led to the synthesis of compound 8, 2-[4-[4-[bis(4- fluorophenyl)methyl]-1-piperazinyl]butyl]-4,4a,5,5a,6,6a-hexa-hydro-4,6- ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione, which demonstrated good H1- antagonist activity. Substitution of a xanthinyl moiety for the polycyclic imide group led to the identification of novel xanthinyl-substituted piperazinyl and piperidinyl derivatives with potent antihistamine H1- activity without the undesirable antidopaminergic activity of 8. One compound, 24, 7-[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]-3,7-dihydro- 1,3-dimethyl-1H-pyrine-2,6-dione (WY-49051), is a potent, orally active H1- antagonist with a long duration of action and a favorable central nervous system profile.