113425-33-5

Basic information

• Product Name: 1-Butanone, 4-hydroxy-1-(4-hydroxyphenyl)-
• CAS NO: 113425-33-5
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 113425-33-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Butanone, 4-hydroxy-1-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 4-hydroxy-1-(4-hydroxyphenyl)-(113425-33-5)
• EPA Substance Registry System: 1-Butanone, 4-hydroxy-1-(4-hydroxyphenyl)-(113425-33-5)

Safety Data

• Hazardous Substances Data: 113425-33-5(Hazardous Substances Data)

Usage

Physical state

Colorless, oily liquid

Classification

Ketones

Uses

Synthesis of pharmaceuticals, fragrances, and flavorings

Natural occurrence

Roots of wild ginger

Potential properties

Antioxidant

Health benefits

Researched for potential health benefits

Upstream product

• 4635-59-0 4-Chlorobutanoyl chloride 
• 108-95-2 phenol 
• 7150-55-2 γ-chloro-4-hydroxybutyrophenone 
• 100-66-3 methoxybenzene 
• 1191-99-7 2,3-dihydro-2H-furan 
• 33527-94-5 4-acetoxyiodobenzene 
• 540-38-5 p-Iodophenol 
• 7446-70-0 aluminium trichloride 
• 65671-24-1 4-bromo-butyric acid phenyl ester 

Downstream Products

• 7150-55-2 γ-chloro-4-hydroxybutyrophenone 
• 36116-18-4 cyclopropyl 4-hydroxyphenyl ketone 
• 56872-39-0 3-(4-hydroxybenzoyl)propionic acid 

Relevant articles and documents

Preparation of cyclopropyl p-hydroxyphenyl ketone and its precursor 3-chloropropyl p-hydroxyphenyl ketone

3-Hydroxypropyl p-hydroxyphenyl ketone (7) is selectively prepared in 96% yield by the Friedel-Crafts reaction of anisole, 4-chlorobutyryl chloride (5) and aluminum chloride in chlorobenzene at 100 °C, followed by quenching the mixture in aqueous hydrochloride at 40 °C. Heating of the quenched aqueous mixture to 100 °C converts hydroxyl compound 7 cleanly to 3-chloropropyl p-hydroxyphenyl ketone (2) in 95-99% yield. Compounds 2 and 7 are interchangeable. Heating chloride 2 with aluminum chloride produces alcohol 7; whereas heating 7 in aqueous hydrochloric acid gives 2 exclusively. The chloride 2 is easily converted to cyclopropyl p-hydroxyphenyl ketone (1) at 0 °C using 6 equiv of aqueous sodium hydroxide or 2 equiv of potassium tert-butoxide in 92 and 96% yields, respectively.