1134880-79-7

Basic information

• Product Name: ([ring-D5]Phe3)-Octreotide
• Synonyms: ([ring-D5]Phe3)-Octreotide;([ring-D5]Phe3)-SMS-201-995, (D-Phe5,Cys6·11,[ring-D5]Phe7,D-Trp8,L-Threoninol12)-SoMatostatin-14 (5-12);H-D-Phe-Cys-[ring-D5]Phe-D-Trp-Lys-Thr-Cys-L-threoninol
• CAS NO: 1134880-79-7
• Molecular Formula: C49H61D5N10O10S2
• Molecular Weight: 1024.27014889
• Mol File: 1134880-79-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ([ring-D5]Phe3)-Octreotide(CAS DataBase Reference)
• NIST Chemistry Reference: ([ring-D5]Phe3)-Octreotide(1134880-79-7)
• EPA Substance Registry System: ([ring-D5]Phe3)-Octreotide(1134880-79-7)

Safety Data

• Hazardous Substances Data: 1134880-79-7(Hazardous Substances Data)

Usage

Description

([ring-D5]Phe3)-Octreotide is a synthetic analog of the hormone somatostatin, characterized by its cyclic octapeptide structure and increased potency compared to the natural hormone. This analog achieves enhanced stability and longer duration of action through the substitution of a deuterated phenylalanine at position 3, which also contributes to its improved pharmacokinetic properties.

Uses

Used in Oncology:
([ring-D5]Phe3)-Octreotide is utilized as an anti-tumor agent for the treatment of specific tumor types, including carcinoid, gastrinoma, and VIPomas. It functions by binding to somatostatin receptors on tumor cells, thereby inhibiting the release of hormones that promote growth and reducing the rate of tumor progression. This targeted approach helps in controlling symptoms and slowing the advancement of the disease in affected patients.