113568-09-5

Basic information

• Product Name: 2-hydroxyethyl 2,6-dimethyl-3-carbethoxy-4-(4-nitrophenyl)-1,4-dihydropyridine-5-carboxylate
• CAS NO: 113568-09-5
• Molecular Weight: 390.393
• Mol File: 113568-09-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-hydroxyethyl 2,6-dimethyl-3-carbethoxy-4-(4-nitrophenyl)-1,4-dihydropyridine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxyethyl 2,6-dimethyl-3-carbethoxy-4-(4-nitrophenyl)-1,4-dihydropyridine-5-carboxylate(113568-09-5)
• EPA Substance Registry System: 2-hydroxyethyl 2,6-dimethyl-3-carbethoxy-4-(4-nitrophenyl)-1,4-dihydropyridine-5-carboxylate(113568-09-5)

Safety Data

• Hazardous Substances Data: 113568-09-5(Hazardous Substances Data)

Upstream product

• 15802-69-4 ethyl 2-(4-nitrobenzylidene)-3-oxobutanoate 
• 33736-01-5 mono(acetoacetate)ethylene glycol 

Relevant articles and documents

Dimeric 1,4-Dihydropyridines as Calcium Channel Antagonists

A series of 1,n-alkanediylbis(1,4-dihydropyridines) (n = 2, 4, 6, 8, 10, 12) bridged at C3 of 2,6-dimethyl-3-carboxy-5-carbethoxy-4-(3-nitrophenyl)-1,4-dihydropyridine were synthesized and evaluated in a radioligand binding assay, nitrendipine in intestinal smooth muscle, as C2+ channel ligands.Binding activity was comparable to that of nitrendipine itself but independent of chain length, suggesting the lack of a major binding contribution by the second 1,4-dihydropyridine group.Analogues lacking the second 1,4-dihydropyridine nucleus or possessing an inactive function (4-nitrophenyl) were no less active, confirming that this series of ligands likely does not bridge adjacent 1,4-dihydropyridine receptors of the Ca2+ channel.