113721-87-2

Basic information

• Product Name: AMCA-NHS
• Synonyms: SUCCINIMIDYL-7-AMINO-4-METHYLCOUMARIN-3-ACETATE;N-SUCCINIMIDYL 7-AMINO-4-METHYL-3-COUMARINYLACETATE;AMCA-NHS;AMCA-OSU;7-AMINO-4-METHYL-3-COUMARINACETIC ACID N-SUCCINIMIDYL ESTER;7-AMINO-4-METHYL-3-COUMARINYLACETYL;7-AMINO-4-METHYL-3-COUMARINYLACETYL SUCCINIMIDYL ESTER;7-(Dimethylamino)coumarin-4-acetic acid-NHS
• CAS NO: 113721-87-2
• Molecular Formula: C16H14N2O6
• Molecular Weight: 330.29
• Product Categories: proteinmod
• Mol File: 113721-87-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 559.4 °C at 760 mmHg
• Flash Point: 292.1 °C
• Appearance: /
• Density: 1.5 g/cm³
• Vapor Pressure: 1.52E-12mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: −20°C
• Solubility: DMF: soluble
• PKA: 1.69±0.20(Predicted)
• BRN: 9007679
• CAS DataBase Reference: AMCA-NHS(CAS DataBase Reference)
• NIST Chemistry Reference: AMCA-NHS(113721-87-2)
• EPA Substance Registry System: AMCA-NHS(113721-87-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 8-10-21
• Hazardous Substances Data: 113721-87-2(Hazardous Substances Data)

Usage

Description

AMCA-NHS, also known as AMCA-N-hydroxysuccinimide, is a fluorescent dye that reacts with primary amines at a pH range of 7.0-9.0. It is commonly used for labeling lysyl residues in proteins, making it a valuable tool in various research and diagnostic applications.

Uses

Used in Research and Diagnostic Applications:
AMCA-NHS is used as a fluorescent labeling agent for lysyl residues in proteins. This allows researchers to track and visualize the proteins of interest in various assays and experiments, providing valuable insights into their structure, function, and interactions.
Used in Bioconjugation:
AMCA-NHS is also used in the process of bioconjugation, where it can be used to attach proteins to other molecules, such as nanoparticles or other biomolecules. This can enhance the properties of the attached molecules, such as their stability, solubility, or targeting capabilities.
Used in Drug Delivery Systems:
In the field of drug delivery, AMCA-NHS can be used to label drug molecules or drug delivery carriers, allowing for the tracking and visualization of their distribution and interactions within biological systems. This can help in optimizing drug delivery strategies and improving therapeutic outcomes.
Used in Analytical Techniques:
AMCA-NHS can be employed in various analytical techniques, such as fluorescence microscopy, flow cytometry, and fluorescence spectroscopy, to detect and quantify the presence of specific proteins or other biomolecules. This can be particularly useful in diagnostics, environmental monitoring, and quality control applications.

InChI:InChI=1/C16H14N2O6/c1-8-10-3-2-9(17)6-12(10)23-16(22)11(8)7-15(21)24-18-13(19)4-5-14(18)20/h2-3,6H,4-5,7,17H2,1H3