1137486-94-2

Basic information

• Product Name: 8-(p-tolyl)-7-benzyl-1,3-dimethyl-xanthine
• Synonyms: 8-(p-tolyl)-7-benzyl-1,3-dimethyl-xanthine
• CAS NO: 1137486-94-2
• Molecular Weight: 360.415
• Mol File: 1137486-94-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 8-(p-tolyl)-7-benzyl-1,3-dimethyl-xanthine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(p-tolyl)-7-benzyl-1,3-dimethyl-xanthine(1137486-94-2)
• EPA Substance Registry System: 8-(p-tolyl)-7-benzyl-1,3-dimethyl-xanthine(1137486-94-2)

Safety Data

• Hazardous Substances Data: 1137486-94-2(Hazardous Substances Data)

Upstream product

• 1807-85-8 7-benzyltheophylline 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 106-43-4 para-chlorotoluene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 5720-05-8 4-methylphenylboronic acid 
• 106-38-7 para-bromotoluene 

Relevant articles and documents

Palladium-catalyzed direct arylation of N-heteroarenes with arylsulfonyl hydrazides

Hydrazides applied: A palladium-catalyzed direct Ci-H arylation of heteroarenes, with arylsulfonyl hydrazides as the arylating reagents, has been developed (see scheme). The reaction is chemoselective, in that arylsulfonyl hydrazides containing halogen substituents can be employed without participation of the halogen substituent in the reaction. The method offers a straightforward approach to a variety of aryl-heteroaryl compounds. Copyright

Palladium-catalyzed desulfitative C-H arylation of heteroarenes with sodium sulfinates

Desulfitative C-H arylation: Palladium-catalyzed desulfitative C-H arylation of heteroarenes with sodium sulfinates has been disclosed to construct aryl-heteroaryl bonds without the need for any extra ligands (see scheme). Copyright

Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst

A new palladium-catalyzed methodology was developed for the direct C-arylation of azoles with a broad spectrum of aryl bromides without the presence of phosphines, the aid of CuI, or other metal additives by using pivalic acid as a cocatalyst. The method also allowed the direct C-arylation of the N-heterocycle N-oxides, and to a lesser degree, the perfluoroaromatics. It was also found that the method can not only be applied to the synthesis of 8-aryl-substituted caffeines, but also 8-arylated theophyllines and theobromines. The result showed thatthe method can tolerate an array of functional groups including ester, nitrile, nitro, aldehyde, methoxy, trifluoromethyl, fluoro, and chloro substituents, and can found its applications in a number of fields such as synthetic and medicinal chemistry both in industry and in academia.